Active ALK dimer binds IRS1

Stable Identifier
R-HSA-9700156
Type
Reaction [binding]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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Phosphorylated tyrosine 1096 is the docking site for IRS1 on the active full length- ALK receptor. IRS-mediated signaling simulates the MAP kinase and PI3K pathways and contributes to cellular proliferation in a manner that depends on ALK kinase activity (Motegi et al, 2004; Kuo et al, 2007; reviewed in Turner and Alexander, 2006; Roskoski, 2013; Della Corte et al, 2018).

Literature References
PubMed ID Title Journal Year
15226403 ALK receptor tyrosine kinase promotes cell growth and neurite outgrowth

Kotani, M, Motegi, A, Sakuraba, H, Fujimoto, J, Yamamoto, T

J. Cell. Sci. 2004
29455642 Role and targeting of anaplastic lymphoma kinase in cancer

Troiani, T, Viscardi, G, Morgillo, F, Fasano, M, Martinelli, E, Ciardiello, F, Della Corte, CM, Di Liello, R

Mol. Cancer 2018
16482213 Fusion tyrosine kinase mediated signalling pathways in the transformation of haematopoietic cells

Turner, SD, Alexander, DR

Leukemia 2006
23201355 Anaplastic lymphoma kinase (ALK): structure, oncogenic activation, and pharmacological inhibition

Roskoski, R

Pharmacol. Res. 2013
16878150 Recruitment of insulin receptor substrate-1 and activation of NF-kappaB essential for midkine growth signaling through anaplastic lymphoma kinase

Kuo, AH, Stoica, GE, Riegel, AT, Wellstein, A

Oncogene 2007
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