Reactome | Active ALK dimer binds IRS1

Active ALK dimer binds IRS1

Stable Identifier

R-HSA-9700156

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

ReviewStatus

5/5

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Phosphorylated tyrosine 1096 is the docking site for IRS1 on the active full length- ALK receptor. IRS-mediated signaling simulates the MAP kinase and PI3K pathways and contributes to cellular proliferation in a manner that depends on ALK kinase activity (Motegi et al, 2004; Kuo et al, 2007; reviewed in Turner and Alexander, 2006; Roskoski, 2013; Della Corte et al, 2018).

Literature References

PubMed ID	Title	Journal	Year
15226403	ALK receptor tyrosine kinase promotes cell growth and neurite outgrowth Kotani, M, Motegi, A, Sakuraba, H, Fujimoto, J, Yamamoto, T	J. Cell. Sci.	2004
29455642	Role and targeting of anaplastic lymphoma kinase in cancer Troiani, T, Viscardi, G, Morgillo, F, Fasano, M, Martinelli, E, Ciardiello, F, Della Corte, CM, Di Liello, R	Mol. Cancer	2018
16482213	Fusion tyrosine kinase mediated signalling pathways in the transformation of haematopoietic cells Turner, SD, Alexander, DR	Leukemia	2006
23201355	Anaplastic lymphoma kinase (ALK): structure, oncogenic activation, and pharmacological inhibition Roskoski, R	Pharmacol. Res.	2013
16878150	Recruitment of insulin receptor substrate-1 and activation of NF-kappaB essential for midkine growth signaling through anaplastic lymphoma kinase Kuo, AH, Stoica, GE, Riegel, AT, Wellstein, A	Oncogene	2007