Reactome | Active ALK dimer binds IRS1

Schema > Reaction > Entries

Active ALK dimer binds IRS1 Show undefined attributes

category	binding
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10434445
displayName	Active ALK dimer binds IRS1
eventOf	[Pathway:R-BTA-201556] Signaling by ALK - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-BTA-9700168] Active ALK phosphorylates IRS1 - Bos taurus
inferredFrom	[Reaction:R-HSA-9700156] Active ALK dimer binds IRS1 - Homo sapiens
input	[CandidateSet:R-BTA-9850879] Active ALK dimer [plasma membrane] [EntityWithAccessionedSequence:R-BTA-74769] IRS1 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Active ALK dimer binds IRS1
output	[Complex:R-BTA-9699993] Active ALK:IRS1 [plasma membrane]
precedingEvent	[Reaction:R-BTA-201521] ALK autophosphorylation - Bos taurus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-9700156
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-201556] Signaling by ALK
(precedingEvent)	[Reaction:R-BTA-9700168] Active ALK phosphorylates IRS1
(inferredTo)	[Reaction:R-HSA-9700156] Active ALK dimer binds IRS1

Cite Us!