Reactome | FLT3 D835V [plasma membrane]

Schema > EntityWithAccessionedSequence > Entries

FLT3 D835V [plasma membrane] Show undefined attributes

compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-HSA-9682347] FLT3 D835V dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-9682347] FLT3 D835V dimer [plasma membrane] - Homo sapiens
created	[InstanceEdit:9682327] Rothfels, Karen, 2020-04-08
crossReference	[DatabaseIdentifier:12020776] Mondo:0018874 [DatabaseIdentifier:9682325] COSMIC:COSV54042199 [DatabaseIdentifier:9682324] COSMIC:COSM36071
dbId	9682323
disease	[Disease:1500689] cancer [Disease:9630839] acute myeloid leukemia
displayName	FLT3 D835V [plasma membrane]
endCoordinate	993
hasModifiedResidue	[ReplacedResidue:9682326] L-aspartic acid 835 replaced with L-valine
inDisease	true
literatureReference	[LiteratureReference:9682272] Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies [LiteratureReference:9695676] Variable sensitivity of FLT3 activation loop mutations to the small molecule tyrosine kinase inhibitor MLN518
maxDepth	1
memberOf	[DefinedSet:R-HSA-9699523] tandutinib-resistant FLT3 mutants [plasma membrane] - Homo sapiens [DefinedSet:R-HSA-9699534] pexidartinib-resistant FLT3 mutants [plasma membrane] - Homo sapiens [DefinedSet:R-HSA-9699530] sorafenib-resistant FLT3 mutants [plasma membrane] - Homo sapiens
modified	[InstanceEdit:9695709] Rothfels, Karen, 2020-07-15
name	FLT3 D835V STK-1
referenceEntity	[ReferenceGeneProduct:uniprot:P36888] UniProt:P36888 FLT3
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-9682323
startCoordinate	27

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[Complex:R-HSA-9682347] FLT3 D835V dimer [plasma membrane]