FURIN Mediated SARS-CoV-2 Spike Protein Cleavage and Endocytosis

Stable Identifier
R-HSA-9699007
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Severe acute respiratory syndrome coronavirus 2
Compartment
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In a SARS-CoV-2 infection the cellular protease furin cleaves the spike protein at the S1/S2 site and that cleavage is essential for S-protein-mediated cell-cell fusion and entry into human lung cells (Hoffman et al. 2020). Furin is associated with the plasma membrane of the host cell and mediates the hydrolytic cleavage of SARS-CoV-2 Spike (S) protein component of the viral membrane-associate S3:M:E:encapsidated SARS coronavirus genomic RNA: 7a:O-glycosyl 3a tetramer complex associated with ACE2.

Literature References
PubMed ID Title Journal Year
21068237 A transmembrane serine protease is linked to the severe acute respiratory syndrome coronavirus receptor and activates virus entry

Shulla, A, Heald-Sargent, T, Subramanya, G, Zhao, J, Perlman, S, Gallagher, T

J. Virol. 2011
32532959 The role of furin cleavage site in SARS-CoV-2 spike protein-mediated membrane fusion in the presence or absence of trypsin

Xia, S, Lan, Q, Su, S, Wang, X, Xu, W, Liu, Z, Zhu, Y, Wang, Q, Lu, L, Jiang, S

Signal Transduct Target Ther 2020
32362314 A Multibasic Cleavage Site in the Spike Protein of SARS-CoV-2 Is Essential for Infection of Human Lung Cells

Hoffmann, M, Kleine-Weber, H, Pöhlmann, S

Mol. Cell 2020
Participants
Participates
Catalyst Activity

serine-type endopeptidase activity of FURIN [plasma membrane]

Disease
Name Identifier Synonyms
COVID-19 DOID:0080600 2019 Novel Coronavirus (2019-nCoV), Wuhan seafood market pneumonia virus infection, 2019-nCoV infection, Wuhan coronavirus infection
Authored
Reviewed
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