FURIN Mediated SARS-CoV-2 Spike Protein Cleavage and Endocytosis

Stable Identifier
Reaction [transition]
Homo sapiens
Related Species
Severe acute respiratory syndrome coronavirus 2
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

In a SARS-CoV-2 infection the cellular protease furin cleaves the spike protein at the S1/S2 site and that cleavage is essential for S-protein-mediated cell-cell fusion and entry into human lung cells (Hoffman et al. 2020). Furin is associated with the plasma membrane of the host cell and mediates the hydrolytic cleavage of SARS-CoV-2 Spike (S) protein component of the viral membrane-associate S3:M:E:encapsidated SARS coronavirus genomic RNA: 7a:O-glycosyl 3a tetramer complex associated with ACE2.

Literature References
PubMed ID Title Journal Year
21068237 A transmembrane serine protease is linked to the severe acute respiratory syndrome coronavirus receptor and activates virus entry

Shulla, A, Heald-Sargent, T, Subramanya, G, Zhao, J, Perlman, S, Gallagher, T

J. Virol. 2011
32532959 The role of furin cleavage site in SARS-CoV-2 spike protein-mediated membrane fusion in the presence or absence of trypsin

Xia, S, Lan, Q, Su, S, Wang, X, Xu, W, Liu, Z, Zhu, Y, Wang, Q, Lu, L, Jiang, S

Signal Transduct Target Ther 2020
32362314 A Multibasic Cleavage Site in the Spike Protein of SARS-CoV-2 Is Essential for Infection of Human Lung Cells

Hoffmann, M, Kleine-Weber, H, Pöhlmann, S

Mol. Cell 2020
Catalyst Activity

serine-type endopeptidase activity of FURIN [plasma membrane]

Name Identifier Synonyms
COVID-19 DOID:0080600 2019 Novel Coronavirus (2019-nCoV), Wuhan seafood market pneumonia virus infection, 2019-nCoV infection, Wuhan coronavirus infection
Cite Us!