Reactome | FLT3 mutant dimers:GRB2 bind SOS1

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FLT3 mutant dimers:GRB2 bind SOS1 Show undefined attributes

authored	[InstanceEdit:9706566] Rothfels, Karen, 2020-11-06
category	binding
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:9695844] Rothfels, Karen, 2020-07-15
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	9695845
disease	[Disease:1500689] cancer
displayName	FLT3 mutant dimers:GRB2 bind SOS1
edited	[InstanceEdit:9706566] Rothfels, Karen, 2020-11-06
entityFunctionalStatus	[EntityFunctionalStatus:9698198] gain_of_function of p-6Y FLT3 mutant dimers:GRB2 [plasma membrane]
eventOf	[Pathway:R-HSA-9703648] Signaling by FLT3 ITD and TKD mutants - Homo sapiens
followingEvent	[Reaction:R-HSA-9695853] FLT3 mutants:GRB2:SOS1-mediated nucleotide exchange on RAS - Homo sapiens
input	[Complex:R-HSA-9695798] p-6Y FLT3 mutant dimers:GRB2 [plasma membrane] [EntityWithAccessionedSequence:R-HSA-64847] SOS1 [cytosol]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:6786755] Flt3 signaling involves tyrosyl-phosphorylation of SHP-2 and SHIP and their association with Grb2 and Shc in Baf3/Flt3 cells [LiteratureReference:9649423] Flt3 mutations from patients with acute myeloid leukemia induce transformation of 32D cells mediated by the Ras and STAT5 pathways [LiteratureReference:9697866] Protein-tyrosine phosphatase DEP-1 controls receptor tyrosine kinase FLT3 signaling [LiteratureReference:9697896] Tandem-duplicated Flt3 constitutively activates STAT5 and MAP kinase and introduces autonomous cell growth in IL-3-dependent cell lines [LiteratureReference:9697839] FMS-like Tyrosine Kinase 3/FLT3: From Basic Science to Clinical Implications
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	FLT3 mutant dimers:GRB2 bind SOS1
normalReaction	[Reaction:R-HSA-9607301] Active FLT3:GRB2 binds SOS1
output	[Complex:R-HSA-9695784] p-6Y FLT3 mutant dimers:GRB2:SOS1 [plasma membrane]
precedingEvent	[Reaction:R-HSA-9695841] FLT3 mutant dimers bind GRB2 - Homo sapiens
releaseDate	2020-12-08
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9706568] Kazi, Julhash U, 2020-11-06
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9695845
summation	[Summation:9697924] SOS1 is presumed to be recruited to FLT3 receptors through i...

Referrals

(precedingEvent)	[Reaction:R-HSA-9695853] FLT3 mutants:GRB2:SOS1-mediated nucleotide exchange on RAS
(hasEvent)	[Pathway:R-HSA-9703648] Signaling by FLT3 ITD and TKD mutants