FLT3 mutants:GRB2:SOS1-mediated nucleotide exchange on RAS

Stable Identifier
R-HSA-9695853
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
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SOS1-mediated nucleotide exchange on RAS downstream of activated FLT3 mutants leads to stimulation of the MAP kinase signaling cascade (Mizuki et al, 2000; Hayakawa et al, 2000; Masson et al, 2009; reviewed in Kazi and Ronnstrand, 2019).

Literature References
PubMed ID Title Journal Year
11090077 Flt3 mutations from patients with acute myeloid leukemia induce transformation of 32D cells mediated by the Ras and STAT5 pathways

Büchner, T, Kratz-Albers, K, Serve, H, Matsumura, I, Müller, C, Serve, S, Steur, C, Kanakura, Y, Berdel, WE, Schmidt, R, Halfter, H, Fenski, R, Grüning, W, Kienast, J, Mizuki, M

Blood 2000
31066629 FMS-like Tyrosine Kinase 3/FLT3: From Basic Science to Clinical Implications

Kazi, JU, Rönnstrand, L

Physiol. Rev. 2019
10698507 Tandem-duplicated Flt3 constitutively activates STAT5 and MAP kinase and introduces autonomous cell growth in IL-3-dependent cell lines

Hayakawa, F, Saito, H, Towatari, M, Tanimoto, M, Naoe, T, Kitamura, T, Kiyoi, H

Oncogene 2000
19438505 A role of Gab2 association in Flt3 ITD mediated Stat5 phosphorylation and cell survival

Masson, K, Sun, J, Khan, R, Liu, T, Rönnstrand, L

Br. J. Haematol. 2009
Participants
Participates
Catalyst Activity

guanyl-nucleotide exchange factor activity of p-6Y FLT3 mutant dimers:GRB2:SOS1 [plasma membrane]

Normal reaction
Functional status

Gain of function of p-6Y FLT3 mutant dimers:GRB2:SOS1 [plasma membrane]

Status
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Authored
Reviewed
Created
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