SOS1-mediated nucleotide exchange on RAS downstream of activated FLT3 mutants leads to stimulation of the MAP kinase signaling cascade (Mizuki et al, 2000; Hayakawa et al, 2000; Masson et al, 2009; reviewed in Kazi and Ronnstrand, 2019).
Kazi, JU, Rönnstrand, L
Masson, K, Liu, T, Khan, R, Sun, J, Rönnstrand, L
Mizuki, M, Fenski, R, Halfter, H, Matsumura, I, Schmidt, R, Müller, C, Grüning, W, Kratz-Albers, K, Serve, S, Steur, C, Büchner, T, Kienast, J, Kanakura, Y, Berdel, WE, Serve, H
Hayakawa, F, Towatari, M, Kiyoi, H, Tanimoto, M, Kitamura, T, Saito, H, Naoe, T
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