SOS1-mediated nucleotide exchange on RAS downstream of activated FLT3 mutants leads to stimulation of the MAP kinase signaling cascade (Mizuki et al, 2000; Hayakawa et al, 2000; Masson et al, 2009; reviewed in Kazi and Ronnstrand, 2019).
Masson, K, Sun, J, Khan, R, Liu, T, Rönnstrand, L
Kazi, JU, Rönnstrand, L
Büchner, T, Kratz-Albers, K, Serve, H, Matsumura, I, Müller, C, Serve, S, Steur, C, Kanakura, Y, Berdel, WE, Schmidt, R, Halfter, H, Fenski, R, Grüning, W, Kienast, J, Mizuki, M
Hayakawa, F, Saito, H, Towatari, M, Tanimoto, M, Naoe, T, Kitamura, T, Kiyoi, H
guanyl-nucleotide exchange factor activity of p-6Y FLT3 mutant dimers:GRB2:SOS1 [plasma membrane]
Gain of function of p-6Y FLT3 mutant dimers:GRB2:SOS1 [plasma membrane]
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