FLT3 mutants:GRB2:SOS1-mediated nucleotide exchange on RAS

Stable Identifier
R-HSA-9695853
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
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FLT3 mutants:GRB2:SOS1-mediated nucleotide exchange on RAS
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SOS1-mediated nucleotide exchange on RAS downstream of activated FLT3 mutants leads to stimulation of the MAP kinase signaling cascade (Mizuki et al, 2000; Hayakawa et al, 2000; Masson et al, 2009; reviewed in Kazi and Ronnstrand, 2019).

Literature References
PubMed ID Title Journal Year
19438505 A role of Gab2 association in Flt3 ITD mediated Stat5 phosphorylation and cell survival

Masson, K, Sun, J, Khan, R, Liu, T, Rönnstrand, L

Br. J. Haematol. 2009
31066629 FMS-like Tyrosine Kinase 3/FLT3: From Basic Science to Clinical Implications

Kazi, JU, Rönnstrand, L

Physiol. Rev. 2019
11090077 Flt3 mutations from patients with acute myeloid leukemia induce transformation of 32D cells mediated by the Ras and STAT5 pathways

Büchner, T, Kratz-Albers, K, Serve, H, Matsumura, I, Müller, C, Serve, S, Steur, C, Kanakura, Y, Berdel, WE, Schmidt, R, Halfter, H, Fenski, R, Grüning, W, Kienast, J, Mizuki, M

Blood 2000
10698507 Tandem-duplicated Flt3 constitutively activates STAT5 and MAP kinase and introduces autonomous cell growth in IL-3-dependent cell lines

Hayakawa, F, Saito, H, Towatari, M, Tanimoto, M, Naoe, T, Kitamura, T, Kiyoi, H

Oncogene 2000
Participants
Input
Output
Participates
as an event of
Catalyst Activity

guanyl-nucleotide exchange factor activity of p-6Y FLT3 mutant dimers:GRB2:SOS1 [plasma membrane]

Physical Entity
p-6Y FLT3 mutant dimers:GRB2:SOS1 [plasma membrane] (Homo sapiens)
Activity
guanyl-nucleotide exchange factor activity (GO:0005085)
Normal reaction
SOS1-mediated nucleotide exchange of RAS downstream of FLT3 (Homo sapiens)
Functional status

Gain of function of p-6Y FLT3 mutant dimers:GRB2:SOS1 [plasma membrane]

Normal Entity
Disease Entity
Status
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Authored
Rothfels, K  (2020-11-06)
Reviewed
Kazi, JU  (2020-11-06)
Created
Rothfels, K  (2020-07-15)
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