3CLp cleaves pp1a

Stable Identifier
R-HSA-9694441
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Severe acute respiratory syndrome coronavirus 2
Compartment
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This COVID-19 event has been created by a combination of computational inference (see https://reactome.org/documentation/inferred-events) from SARS-CoV-1 data and manual curation, as described in the summation for the overall SARS-CoV-2 infection pathway.

Main protease cleaves all cleavage sites of pp1a and ppa1b starting with nsp4/5, thus cleaving itself, and all the cytosolic RTC proteins (Fan et al, 2004)

Literature References
PubMed ID Title Journal Year
14561748 Biosynthesis, purification, and substrate specificity of severe acute respiratory syndrome coronavirus 3C-like proteinase

Fan, K, Wei, P, Feng, Q, Chen, S, Huang, C, Ma, L, Lai, B, Pei, J, Liu, Y, Chen, J, Lai, L

J. Biol. Chem. 2004
Participants
Participates
Catalyst Activity

cysteine-type endopeptidase activity of 3CLp dimer [cytosol]

This event is regulated
Inferred From
Disease
Name Identifier Synonyms
COVID-19 DOID:0080600 2019 Novel Coronavirus (2019-nCoV), Wuhan seafood market pneumonia virus infection, 2019-nCoV infection, Wuhan coronavirus infection
Authored
Reviewed
Created
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