Reactome | The nsp7:nsp8 heterodimer binds to the RNA-directed RNA poly...

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created	[InstanceEdit:9691362] Orlic-Milacic, Marija, 2020-06-11
dbId	9691361
displayName	The nsp7:nsp8 heterodimer binds to the RNA-directed RNA poly...
literatureReference	[LiteratureReference:9691337] Structure of the RNA-dependent RNA polymerase from COVID-19 virus [LiteratureReference:9680809] Structure of the SARS-CoV nsp12 polymerase bound to nsp7 and nsp8 co-factors [LiteratureReference:9696799] Virus-Host Interactome and Proteomic Survey Reveal Potential Virulence Factors Influencing SARS-CoV-2 Pathogenesis [LiteratureReference:9697109] Structure of replicating SARS-CoV-2 polymerase [LiteratureReference:9697280] Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir
modified	[InstanceEdit:9762525] Stephan, Ralf, 2022-01-26
schemaClass	Summation
text	The nsp7:nsp8 heterodimer binds to the RNA-directed RNA polymerase (nsp12) of the SARS-CoV-2 (Gao et al. 2020, Li et al. 2020, Hillen et al. 2020). The second subunit of nsp8, not bound to nsp7, interacts with a different region of nsp12 (Gao et al. 2020, Yin et al. 2020; Courouble et al, 2021; Biswal et al, 2021), as previously found in SARS-CoV-1 (Kirchdoerfer and Ward 2019).

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