nsp12 binds nsp7 and nsp8

Stable Identifier
R-HSA-9691363
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Severe acute respiratory syndrome coronavirus 2
Compartment
cytosol
ReviewStatus
5/5
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nsp12 binds nsp7 and nsp8
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The nsp7:nsp8 heterodimer binds to the RNA-directed RNA polymerase (nsp12) of the SARS-CoV-2 (Gao et al. 2020, Li et al. 2020, Hillen et al. 2020). The second subunit of nsp8, not bound to nsp7, interacts with a different region of nsp12 (Gao et al. 2020, Yin et al. 2020; Courouble et al, 2021; Biswal et al, 2021), as previously found in SARS-CoV-1 (Kirchdoerfer and Ward 2019).
Literature References
PubMed ID Title Journal Year
32838362 Virus-Host Interactome and Proteomic Survey Reveal Potential Virulence Factors Influencing SARS-CoV-2 Pathogenesis

Liang, Q, Liu, C, Zhu, Z, Qu, Y, Zhu, T, Zhang, Y, Xiao, Z, Wu, P, Li, J, Yang, X, Yin, Y, Wang, C, Guo, M, Liu, Z, Tian, X, Wang, X, Peng, C

Med (N Y) 2020
32277040 Structure of the RNA-dependent RNA polymerase from COVID-19 virus

Lou, Z, Gao, Y, Zhang, B, Zhu, C, Yang, H, Yan, L, Liu, Z, Zheng, L, Wang, T, Hu, T, Xu, W, Yang, X, Wang, Q, Li, J, Liu, F, Rao, Z, Zhang, Y, Huang, Y, Zhao, Y, Cao, L, Zhu, Y, Zhang, L, Ming, Z, Ge, J, Wang, H, Guddat, LW, Hua, T, Sun, Q

Science 2020
34121407 Revealing the Structural Plasticity of SARS-CoV-2 nsp7 and nsp8 Using Structural Proteomics

Dey, SK, Arnold, E, Ruiz, FX, Timm, J, Courouble, VV, Harrison, JJEK, Griffin, PR, Yadav, R

J Am Soc Mass Spectrom 2021
32531208 Structural and Biochemical Characterization of the nsp12-nsp7-nsp8 Core Polymerase Complex from SARS-CoV-2

Yuan, B, Gao, GF, Wang, Q, Peng, R, Shi, Y, Sun, Y, Fan, Z, Peng, Q, Qi, J, Wang, X, Wang, M, Zhao, J

Cell Rep 2020
32438371 Structure of replicating SARS-CoV-2 polymerase

Dienemann, C, Tegunov, D, Cramer, P, Farnung, L, Kokic, G, Hillen, HS

Nature 2020
32358203 Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir

Jiang, Y, Wang, X, Shen, DD, Su, H, Tao, SC, Xie, YC, Zhang, Y, Gao, M, Jiang, H, Mao, C, Xu, HE, Zhang, S, Shen, J, Zhou, F, Luan, X, Jiang, HW, Yin, W, Zhao, W, Xu, Y, Shen, Q, Tian, G, Chang, S

Science 2020
33999154 Two conserved oligomer interfaces of NSP7 and NSP8 underpin the dynamic assembly of SARS-CoV-2 RdRP

Fang, J, Biswal, M, Lu, J, Diggs, S, Khudaverdyan, N, Hai, R, Song, J, Xu, D, Blaha, G

Nucleic Acids Res 2021
Participants
Input
Output
Participates
as an event of
Disease
Name Identifier Synonyms
COVID-19 DOID:0080600 2019 Novel Coronavirus (2019-nCoV), Wuhan seafood market pneumonia virus infection, 2019-nCoV infection, Wuhan coronavirus infection
Authored
Orlic-Milacic, M  (2020-08-12)
Senff-Ribeiro, A  (2020-08-12)
Reviewed
Acencio, ML  (2020-09-09)
Created
Orlic-Milacic, M  (2020-06-11)
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