Reactome | nsp12:2Fe4S4 [cytosol]

Schema > Complex > Entries

authored	[InstanceEdit:9771684] Stephan, Ralf, 2022-04-20
compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-COV-9691364] nsp7:nsp8:nsp12 [cytosol] - Severe acute respiratory syndrome coronavirus 2
consumedByEvent	[Reaction:R-HSA-9691363] nsp12 binds nsp7 and nsp8 - Homo sapiens
created	[InstanceEdit:9771678] Stephan, Ralf, 2022-04-20
crossReference	[DatabaseIdentifier:12020746] Mondo:0100096
dbId	9771682
disease	[Disease:9683912] COVID-19
displayName	nsp12:2Fe4S4 [cytosol]
hasComponent	2 × [SimpleEntity:R-ALL-937126] (4Fe-4S)(2+) [cytosol] [EntityWithAccessionedSequence:R-COV-9682057] pp1ab-nsp12 [cytosol]
inDisease	true
isChimeric	false
literatureReference	[LiteratureReference:9771687] Fe-S cofactors in the SARS-CoV-2 RNA-dependent RNA polymerase are potential antiviral targets
maxDepth	2
modified	[InstanceEdit:9773828] Stephan, Ralf, 2022-05-10
name	nsp12:2Fe4S4
producedByEvent	[BlackBoxEvent:R-HSA-9771686] nsp12 acquires Fe-S cluster cofactors - Homo sapiens
schemaClass	Complex
species	[Species:9681683] Severe acute respiratory syndrome coronavirus 2
stId	R-COV-9771682

(output)	[BlackBoxEvent:R-HSA-9771686] nsp12 acquires Fe-S cluster cofactors
(input)	[Reaction:R-HSA-9691363] nsp12 binds nsp7 and nsp8
(hasComponent)	[Complex:R-COV-9691364] nsp7:nsp8:nsp12 [cytosol]

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