Reactome | Aberrant regulation of mitotic exit in cancer due to RB1 defects

Schema > Pathway > Entries

authored	[InstanceEdit:9687445] Orlic-Milacic, Marija, 2020-05-07
created	[InstanceEdit:9687137] Orlic-Milacic, Marija, 2020-05-06
crossReference	[DatabaseIdentifier:12819491] BioModels Database:BIOMD0000000186 [DatabaseIdentifier:12020745] Mondo:0004992 [DatabaseIdentifier:12819493] BioModels Database:BIOMD0000000187 [DatabaseIdentifier:12819589] BioModels Database:BIOMD0000000954
dbId	9687136
disease	[Disease:1500689] cancer
displayName	Aberrant regulation of mitotic exit in cancer due to RB1 defects
edited	[InstanceEdit:9689368] Orlic-Milacic, Marija, 2020-05-18
eventOf	[Pathway:R-HSA-9687139] Aberrant regulation of mitotic cell cycle due to RB1 defects - Homo sapiens
hasDiagram	true
hasEHLD	false
hasEvent	[FailedReaction:R-HSA-9687377] Defective RB1 does not form a complex with SKP2 and FZR1 - Homo sapiens
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9661115] RB1: a prototype tumor suppressor and an enigma
maxDepth	2
modified	[InstanceEdit:12819426] Weiser, Joel, 2026-02-23
name	Aberrant regulation of mitotic exit in cancer due to RB1 defects
normalPathway	[Pathway:R-HSA-453276] Regulation of mitotic cell cycle
releaseDate	2020-06-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9689366] Dick, Frederick Andrew, 2020-05-17
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-9687136
summation	[Summation:9687150] RB1 regulates mitotic exit by acting on SKP2, a component of...

(hasEvent)

Cite Us!