Reactome | APC/C:Cdh1 polyubiquitinates SKP2

Schema > Reaction > Entries

APC/C:Cdh1 polyubiquitinates SKP2 Show undefined attributes

catalystActivity	[CatalystActivity:10904373] ubiquitin protein ligase activity of RB1:SKP2:APC/C:Cdh1 [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10904375
displayName	APC/C:Cdh1 polyubiquitinates SKP2
eventOf	[Pathway:R-DME-174178] APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[BlackBoxEvent:R-DME-188191] APC/C:Cdh1-mediated degradation of Skp2 - Drosophila melanogaster
inferredFrom	[Reaction:R-HSA-9686969] APC/C:Cdh1 polyubiquitinates SKP2 - Homo sapiens
input	[Complex:R-DME-9686978] RB1:SKP2:APC/C:Cdh1 [nucleoplasm] 3 × [DefinedSet:R-DME-68524] Ub [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	APC/C:Cdh1 polyubiquitinates SKP2
output	[Complex:R-DME-188192] PolyUb-SKP2:RB1:phospho-APC/C:Cdh1 complex [nucleoplasm]
precedingEvent	[Reaction:R-DME-9686980] RB1 recruits APC/C:Cdh1 complex to SKP2 - Drosophila melanogaster
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:56210] Drosophila melanogaster
stId	R-DME-9686969
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-174178] APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
(precedingEvent)	[BlackBoxEvent:R-DME-188191] APC/C:Cdh1-mediated degradation of Skp2
(inferredTo)	[Reaction:R-HSA-9686969] APC/C:Cdh1 polyubiquitinates SKP2