Reactome | tandutinib-resistant FLT3 mutants [plasma membrane]

Schema > DefinedSet > Entries

compartment	[Compartment:876] plasma membrane
consumedByEvent	[FailedReaction:R-HSA-9702638] tandutinib-resistant FLT3 mutants don't bind tandutinib - Homo sapiens
created	[InstanceEdit:9699524] Rothfels, Karen, 2020-09-14
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	9699523
disease	[Disease:1500689] cancer
displayName	tandutinib-resistant FLT3 mutants [plasma membrane]
hasMember	[EntityWithAccessionedSequence:R-HSA-9695715] FLT3 D835del [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9682323] FLT3 D835V [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9682353] FLT3 D835Y [plasma membrane] - Homo sapiens
inDisease	true
literatureReference	[LiteratureReference:9695676] Variable sensitivity of FLT3 activation loop mutations to the small molecule tyrosine kinase inhibitor MLN518 [LiteratureReference:9699359] Selective FLT3 inhibition of FLT3-ITD+ acute myeloid leukaemia resulting in secondary D835Y mutation: a model for emerging clinical resistance patterns
maxDepth	2
name	tandutinib-resistant FLT3 mutants
schemaClass	DefinedSet
species	[Species:48887] Homo sapiens
stId	R-HSA-9699523

(input)	[FailedReaction:R-HSA-9702638] tandutinib-resistant FLT3 mutants don't bind tandutinib
(diseaseEntity)	[EntityFunctionalStatus:9702637] loss_of_function of tandutinib-resistant FLT3 mutants [plasma membrane]

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