Reactome | KIT [plasma membrane]

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KIT [plasma membrane] Show undefined attributes

compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-HSA-205166] KIT:sSCF dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-9681373] KIT:ripretinib [plasma membrane] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-205321] Interaction of KIT and sSCF - Homo sapiens [Reaction:R-HSA-205231] Dimerization of KIT upon SCF binding - Homo sapiens [Reaction:R-HSA-9681375] KIT binds ripretinib - Homo sapiens [Reaction:R-HSA-1433423] PTP-RO interacts with p-c-Kit complex - Homo sapiens [Reaction:R-HSA-9669854] KIT binds type II TKIs - Homo sapiens [Reaction:R-HSA-1433508] PKC alpha interacts with and phosphorylates KIT - Homo sapiens
created	[InstanceEdit:197663] de Bono, B, 2007-05-14 15:28:49
dbId	197662
displayName	KIT [plasma membrane]
endCoordinate	976
inDisease	false
inferredTo	[EntityWithAccessionedSequence:R-MMU-197662] KIT [plasma membrane] - Mus musculus [EntityWithAccessionedSequence:R-RNO-197662] KIT [plasma membrane] - Rattus norvegicus [EntityWithAccessionedSequence:R-CFA-197662] KIT [plasma membrane] - Canis familiaris [EntityWithAccessionedSequence:R-BTA-197662] KIT [plasma membrane] - Bos taurus [EntityWithAccessionedSequence:R-SSC-197662] KIT [plasma membrane] - Sus scrofa [EntityWithAccessionedSequence:R-DRE-197662] KIT [plasma membrane] - Danio rerio [EntityWithAccessionedSequence:R-XTR-197662] KIT [plasma membrane] - Xenopus tropicalis [EntityWithAccessionedSequence:R-GGA-197662] KIT [plasma membrane] - Gallus gallus [EntityWithAccessionedSequence:R-DME-197662] KIT [plasma membrane] - Drosophila melanogaster [EntityWithAccessionedSequence:R-CEL-197662] kin-36 [plasma membrane] - Caenorhabditis elegans [EntityWithAccessionedSequence:R-CEL-197662-2] KIT [plasma membrane] - Caenorhabditis elegans [EntityWithAccessionedSequence:R-CEL-197662-3] kin-9 [plasma membrane] - Caenorhabditis elegans [EntityWithAccessionedSequence:R-CEL-197662-4] KIT [plasma membrane] - Caenorhabditis elegans [EntityWithAccessionedSequence:R-CEL-197662-5] kin-30 [plasma membrane] - Caenorhabditis elegans [EntityWithAccessionedSequence:R-CEL-197662-6] flor-1 [plasma membrane] - Caenorhabditis elegans [EntityWithAccessionedSequence:R-CEL-197662-7] KIT [plasma membrane] - Caenorhabditis elegans [EntityWithAccessionedSequence:R-CEL-197662-8] KIT [plasma membrane] - Caenorhabditis elegans [EntityWithAccessionedSequence:R-CEL-197662-9] KIT [plasma membrane] - Caenorhabditis elegans [EntityWithAccessionedSequence:R-CEL-197662-10] KIT [plasma membrane] - Caenorhabditis elegans [EntityWithAccessionedSequence:R-CEL-197662-11] KIT [plasma membrane] - Caenorhabditis elegans [EntityWithAccessionedSequence:R-CEL-197662-12] KIT [plasma membrane] - Caenorhabditis elegans [EntityWithAccessionedSequence:R-CEL-197662-13] KIT [plasma membrane] - Caenorhabditis elegans [EntityWithAccessionedSequence:R-CEL-197662-14] KIT [plasma membrane] - Caenorhabditis elegans [EntityWithAccessionedSequence:R-CEL-197662-15] KIT [plasma membrane] - Caenorhabditis elegans [EntityWithAccessionedSequence:R-CEL-197662-16] KIT [plasma membrane] - Caenorhabditis elegans [EntityWithAccessionedSequence:R-CEL-197662-17] KIT [plasma membrane] - Caenorhabditis elegans [EntityWithAccessionedSequence:R-CEL-197662-18] KIT [plasma membrane] - Caenorhabditis elegans [DefinedSet:R-CEL-197662-19] Homologues of KIT [plasma membrane] - Caenorhabditis elegans
markingReferences	[MarkerReference:9960442] KIT [plasma membrane] Transcriptome analyses of mouse and human mammary cell subpopulations reveal multiple conserved genes and pathways
maxDepth	1
modified	[InstanceEdit:9748869] Orlic-Milacic, Marija, 2021-07-27
name	KIT Mast/stem cell growth factor receptor precursor KIT_HUMAN c-KIT CD117
producedByEvent	[BlackBoxEvent:R-HSA-8864698] KIT gene expression is stimulated by TFAP2A,(TFAP2B) homodimers - Homo sapiens
referenceEntity	[ReferenceGeneProduct:uniprot:P10721] UniProt:P10721 KIT
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-197662
startCoordinate	26
updateTrackers	[UpdateTracker:9897067] Update Tracker - [EntityWithAccessionedSequence:197662] KIT [plasma membrane] - v61:[addName] [UpdateTracker:9902709] Update Tracker - [EntityWithAccessionedSequence:197662] KIT [plasma membrane] - v78:[addName]

Referrals

(hasComponent)	[Complex:R-HSA-205166] KIT:sSCF dimer [plasma membrane] [Complex:R-HSA-205208] KIT:sSCF dimer:KIT [plasma membrane] [Complex:R-HSA-9669721] KIT:type II TKIs [plasma membrane] [Complex:R-HSA-9681373] KIT:ripretinib [plasma membrane] [Complex:R-HSA-1433419] PTPRU:KIT [plasma membrane]
(input)	[Reaction:R-HSA-205321] Interaction of KIT and sSCF [Reaction:R-HSA-205231] Dimerization of KIT upon SCF binding [Reaction:R-HSA-9681375] KIT binds ripretinib [Reaction:R-HSA-1433423] PTP-RO interacts with p-c-Kit complex [Reaction:R-HSA-9669854] KIT binds type II TKIs [Reaction:R-HSA-1433508] PKC alpha interacts with and phosphorylates KIT
(output)	[BlackBoxEvent:R-HSA-8864698] KIT gene expression is stimulated by TFAP2A,(TFAP2B) homodimers
(normalEntity)	[EntityFunctionalStatus:9669860] loss_of_function of imatinib resistant KIT mutants [plasma membrane] [EntityFunctionalStatus:9669880] loss_of_function of sunitinib resistant KIT mutants [plasma membrane] [EntityFunctionalStatus:9669871] loss_of_function of regorafenib-resistant KIT mutants [plasma membrane] [EntityFunctionalStatus:9669853] loss_of_function of dasatinib resistant KIT mutants [plasma membrane] [EntityFunctionalStatus:9669864] loss_of_function of masitinib resistant KIT mutants [plasma membrane] [EntityFunctionalStatus:9669866] loss_of_function of nilotinib resistant KIT mutants [plasma membrane] [EntityFunctionalStatus:9686617] gain_of_function of ripretinib-sensitive KIT mutants [plasma membrane] [EntityFunctionalStatus:9669902] gain_of_function of type II TKI sensitive KIT mutants [plasma membrane] [EntityFunctionalStatus:9669876] loss_of_function of sorafenib resistant KIT mutants [plasma membrane]
(marker)	[MarkerReference:9960442] KIT [plasma membrane] Transcriptome analyses of mouse and human mammary cell subpopulations reveal multiple conserved genes and pathways
(proteinMarker)	[Cell:R-HSA-9927424] hormone receptor negative mammary luminal progenitor cell
(updatedInstance)	[UpdateTracker:9897067] Update Tracker - [EntityWithAccessionedSequence:197662] KIT [plasma membrane] - v61:[addName] [UpdateTracker:9902709] Update Tracker - [EntityWithAccessionedSequence:197662] KIT [plasma membrane] - v78:[addName]

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