Reactome | ripretinib [cytosol]

Schema > ChemicalDrug > Entries

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-HSA-9681383] ripretinib-sensitive KIT:ripretinib [plasma membrane] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-9681382] KIT mutants bind ripretinib - Homo sapiens [Reaction:R-CEL-9681375] KIT binds ripretinib - Caenorhabditis elegans [Reaction:R-GGA-9681375] KIT binds ripretinib - Gallus gallus [Reaction:R-XTR-9681375] KIT binds ripretinib - Xenopus tropicalis [Reaction:R-DRE-9681375] KIT binds ripretinib - Danio rerio [Reaction:R-SSC-9681375] KIT binds ripretinib - Sus scrofa [Reaction:R-BTA-9681375] KIT binds ripretinib - Bos taurus [Reaction:R-CFA-9681375] KIT binds ripretinib - Canis familiaris [Reaction:R-RNO-9681375] KIT binds ripretinib - Rattus norvegicus [Reaction:R-MMU-9681375] KIT binds ripretinib - Mus musculus [Reaction:R-HSA-9681375] KIT binds ripretinib - Homo sapiens [Reaction:R-DME-9681375] KIT binds ripretinib - Drosophila melanogaster
created	[InstanceEdit:9674324] Rothfels, Karen, 2020-01-13
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	9674322
disease	[Disease:1500689] cancer
displayName	ripretinib [cytosol]
inDisease	true
maxDepth	1
memberOf	[DefinedSet:R-ALL-9674079] type II PDGFR-binding tyrosine kinase inhibitors [cytosol]
name	ripretinib DCC2618 DCC-2618
referenceEntity	[ReferenceTherapeutic:iuphar.ligand:9175] ripretinib [Guide to Pharmacology:9175]
schemaClass	ChemicalDrug
stId	R-ALL-9674322

(hasComponent)	[Complex:R-HSA-9681383] ripretinib-sensitive KIT:ripretinib [plasma membrane] [Complex:R-CFA-9681373] KIT:ripretinib [plasma membrane] [Complex:R-XTR-9681373] KIT:ripretinib [plasma membrane] [Complex:R-DME-9681373] KIT:ripretinib [plasma membrane] [Complex:R-DRE-9681373] KIT:ripretinib [plasma membrane] [Complex:R-MMU-9681373] KIT:ripretinib [plasma membrane] [Complex:R-CEL-9681373] KIT:ripretinib [plasma membrane] [Complex:R-SSC-9681373] KIT:ripretinib [plasma membrane] [Complex:R-RNO-9681373] KIT:ripretinib [plasma membrane] [Complex:R-GGA-9681373] KIT:ripretinib [plasma membrane] [Complex:R-HSA-9681373] KIT:ripretinib [plasma membrane] [Complex:R-BTA-9681373] KIT:ripretinib [plasma membrane]
(input)	[Reaction:R-HSA-9681382] KIT mutants bind ripretinib [Reaction:R-CEL-9681375] KIT binds ripretinib [Reaction:R-GGA-9681375] KIT binds ripretinib [Reaction:R-XTR-9681375] KIT binds ripretinib [Reaction:R-DRE-9681375] KIT binds ripretinib [Reaction:R-SSC-9681375] KIT binds ripretinib [Reaction:R-BTA-9681375] KIT binds ripretinib [Reaction:R-CFA-9681375] KIT binds ripretinib [Reaction:R-RNO-9681375] KIT binds ripretinib [Reaction:R-MMU-9681375] KIT binds ripretinib [Reaction:R-HSA-9681375] KIT binds ripretinib [Reaction:R-DME-9681375] KIT binds ripretinib
(activeUnit)	[NegativeRegulation:9681372] Negative regulation by 'KIT:ripretinib [plasma membrane]'
(hasMember)	[DefinedSet:R-ALL-9674079] type II PDGFR-binding tyrosine kinase inhibitors [cytosol]

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