Reactome | KIT binds ripretinib

Schema > Reaction > Entries

category	binding
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10904306
displayName	KIT binds ripretinib
eventOf	[Pathway:R-DME-1433557] Signaling by SCF-KIT - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-9681375] KIT binds ripretinib - Homo sapiens
input	[EntityWithAccessionedSequence:R-DME-197662] KIT [plasma membrane] [ChemicalDrug:R-ALL-9674322] ripretinib [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	KIT binds ripretinib
output	[Complex:R-DME-9681373] KIT:ripretinib [plasma membrane]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:56210] Drosophila melanogaster
stId	R-DME-9681375
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-DME-1433557] Signaling by SCF-KIT
(inferredTo)	[Reaction:R-HSA-9681375] KIT binds ripretinib

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