Reactome | Formation of the SET1B complex

Schema > Reaction > Entries

Formation of the SET1B complex Show undefined attributes

authored	[InstanceEdit:9823562] Orlic-Milacic, Marija, 2023-01-06
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9676262] Orlic-Milacic, Marija, 2020-02-11
dbId	9676264
displayName	Formation of the SET1B complex
edited	[InstanceEdit:9828330] Orlic-Milacic, Marija, 2023-02-13
eventOf	[Pathway:R-HSA-9772755] Formation of WDR5-containing histone-modifying complexes - Homo sapiens
followingEvent	[Reaction:R-HSA-9821476] CXXC1 and WDR82 bind SET1B complex - Homo sapiens [Reaction:R-HSA-5244692] Core MLL complex, SMYD3, PRDM9 methylate dimethyl-lysine-5 of histone H3 (H3K4) - Homo sapiens [Reaction:R-HSA-5637686] WHSC1L1 (KMT3F), Core MLL complex, SMYD3 (KMT3E) methylate methyl-lysine-5 of histone H3 (H3K4) - Homo sapiens [Reaction:R-HSA-5159245] SETD3, SETD7 (KMT7), WHSC1L1 (KMT3F), Core MLL complex methylate lysine-5 of histone H3 (H3K4) - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-5244714] SETD1B [nucleoplasm] [Complex:R-HSA-9675213] WRAD complex [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9676266] The plasticity of WDR5 peptide-binding cleft enables the binding of the SET1 family of histone methyltransferases [LiteratureReference:9772102] Targeted Disruption of the Interaction between WD-40 Repeat Protein 5 (WDR5) and Mixed Lineage Leukemia (MLL)/SET1 Family Proteins Specifically Inhibits MLL1 and SETd1A Methyltransferase Complexes [LiteratureReference:9772762] Quantitative dissection and stoichiometry determination of the human SET1/MLL histone methyltransferase complexes [LiteratureReference:9772918] Identification and characterization of the human Set1B histone H3-Lys4 methyltransferase complex
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	Formation of the SET1B complex
orthologousEvent	[Reaction:R-SCE-9676264] Formation of the SET1B complex - Saccharomyces cerevisiae [Reaction:R-SPO-9676264] Formation of the SET1B complex - Schizosaccharomyces pombe [Reaction:R-DDI-9676264] Formation of the SET1B complex - Dictyostelium discoideum [Reaction:R-CEL-9676264] Formation of the SET1B complex - Caenorhabditis elegans [Reaction:R-DME-9676264] Formation of the SET1B complex - Drosophila melanogaster [Reaction:R-GGA-9676264] Formation of the SET1B complex - Gallus gallus [Reaction:R-SSC-9676264] Formation of the SET1B complex - Sus scrofa [Reaction:R-BTA-9676264] Formation of the SET1B complex - Bos taurus [Reaction:R-CFA-9676264] Formation of the SET1B complex - Canis familiaris [Reaction:R-RNO-9676264] Formation of the SET1B complex - Rattus norvegicus [Reaction:R-MMU-9676264] Formation of the SET1B complex - Mus musculus
output	[Complex:R-HSA-9676269] SET1B complex [nucleoplasm]
precedingEvent	[Reaction:R-HSA-9675214] Formation of the WRAD complex - Homo sapiens
releaseDate	2023-03-29
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9827909] Van, Hieu, 2023-02-08 [InstanceEdit:9827910] Ge, Kai, 2023-02-08
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9676264
summation	[Summation:9676270] SETD1B (also known as SET1B) binds the WRAD complex, consist...

Referrals

(hasEvent)

[Pathway:R-HSA-9772755] Formation of WDR5-containing histone-modifying complexes

(precedingEvent)

[Reaction:R-HSA-9821476] CXXC1 and WDR82 bind SET1B complex
[Reaction:R-HSA-5244692] Core MLL complex, SMYD3, PRDM9 methylate dimethyl-lysine-5 of histone H3 (H3K4)
[Reaction:R-HSA-5637686] WHSC1L1 (KMT3F), Core MLL complex, SMYD3 (KMT3E) methylate methyl-lysine-5 of histone H3 (H3K4)
[Reaction:R-HSA-5159245] SETD3, SETD7 (KMT7), WHSC1L1 (KMT3F), Core MLL complex methylate lysine-5 of histone H3 (H3K4)

Cite Us!