Reactome | Formation of the WRAD complex

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Formation of the WRAD complex Show undefined attributes

authored	[InstanceEdit:9823562] Orlic-Milacic, Marija, 2023-01-06
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9675217] Orlic-Milacic, Marija, 2020-02-03
dbId	9675214
displayName	Formation of the WRAD complex
edited	[InstanceEdit:9828330] Orlic-Milacic, Marija, 2023-02-13
eventOf	[Pathway:R-HSA-9772755] Formation of WDR5-containing histone-modifying complexes - Homo sapiens
followingEvent	[Reaction:R-HSA-9676268] Formation of the MLL4 complex - Homo sapiens [Reaction:R-HSA-9676254] Formation of the MLL3 complex - Homo sapiens [Reaction:R-HSA-9676255] Formation of the MLL2 complex - Homo sapiens [Reaction:R-HSA-9676264] Formation of the SET1B complex - Homo sapiens [Reaction:R-HSA-9676257] Formation of the SET1A complex - Homo sapiens [Reaction:R-HSA-9675026] Formation of the MLL1 complex - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-5669104] DPY30 [nucleoplasm] [Complex:R-HSA-9675216] RBBP5:ASH2L [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-1629838] WDR5 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:4687068] PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex [LiteratureReference:9675716] Biochemical reconstitution and phylogenetic comparison of human SET1 family core complexes involved in histone methylation [LiteratureReference:9675721] A novel non-SET domain multi-subunit methyltransferase required for sequential nucleosomal histone H3 methylation by the mixed lineage leukemia protein-1 (MLL1) core complex [LiteratureReference:9675715] WRAD: enabler of the SET1-family of H3K4 methyltransferases [LiteratureReference:9772884] Characterization of a novel WDR5-binding site that recruits RbBP5 through a conserved motif to enhance methylation of histone H3 lysine 4 by mixed lineage leukemia protein-1 [LiteratureReference:9772762] Quantitative dissection and stoichiometry determination of the human SET1/MLL histone methyltransferase complexes
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Formation of the WRAD complex
output	[Complex:R-HSA-9675213] WRAD complex [nucleoplasm]
precedingEvent	[Reaction:R-HSA-9675215] Formation of the RBBP5:ASH2L heterodimer - Homo sapiens
releaseDate	2023-03-29
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9827909] Van, Hieu, 2023-02-08 [InstanceEdit:9827910] Ge, Kai, 2023-02-08
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9675214
summation	[Summation:9675703] WDR5 and DPY30 interact with the RBBP5:ASH2L heterodimer and...

Referrals

(hasEvent)	[Pathway:R-HSA-9772755] Formation of WDR5-containing histone-modifying complexes
(precedingEvent)	[Reaction:R-HSA-9676268] Formation of the MLL4 complex [Reaction:R-HSA-9676254] Formation of the MLL3 complex [Reaction:R-HSA-9676255] Formation of the MLL2 complex [Reaction:R-HSA-9676264] Formation of the SET1B complex [Reaction:R-HSA-9676257] Formation of the SET1A complex [Reaction:R-HSA-9675026] Formation of the MLL1 complex

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