Reactome | Formation of the SET1B complex

Formation of the SET1B complex

Stable Identifier

R-HSA-9676264

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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SETD1B (also known as SET1B) binds the WRAD complex, consisting of WDR5, RBBP5, ASH2L and DPY30, to form the SET1B complex (Lee et al. 2007; Zhang et al. 2012; van Nuland et al. 2013; Alicea-Velazquez et al. 2016). WDR5 plays an important role in the optimal stimulation of SET1B methyltransferase activity by the RBBP5:ASH2L heterodimer (Zhang et al. 2012).

Literature References

PubMed ID	Title	Journal	Year
23508102	Quantitative dissection and stoichiometry determination of the human SET1/MLL histone methyltransferase complexes Pallaki, P, Smits, AH, van Nuland, R, Jansen, PW, Timmers, HT, Vermeulen, M	Mol Cell Biol	2013
22266653	The plasticity of WDR5 peptide-binding cleft enables the binding of the SET1 family of histone methyltransferases Couture, JF, Brunzelle, JS, Zhang, P, Lee, H	Nucleic Acids Res.	2012
17355966	Identification and characterization of the human Set1B histone H3-Lys4 methyltransferase complex Skalnik, DG, Tate, CM, You, JS, Lee, JH	J Biol Chem	2007
27563068	Targeted Disruption of the Interaction between WD-40 Repeat Protein 5 (WDR5) and Mixed Lineage Leukemia (MLL)/SET1 Family Proteins Specifically Inhibits MLL1 and SETd1A Methyltransferase Complexes Skalnik, DG, Cosgrove, MS, Shinsky, SA, Alicea-Velázquez, NL, Lee, JH, Loh, DM	J Biol Chem	2016