Reactome | PDGFRs bind type I TKI

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PDGFRs bind type I TKI Show undefined attributes

authored	[InstanceEdit:9677035] Rothfels, Karen, 2020-02-25
category	binding
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:9674092] Rothfels, Karen, 2020-01-10
dbId	9674093
diseaseReaction	[Reaction:R-HSA-9674427] PDGFR mutants bind type I TKIs - Homo sapiens
displayName	PDGFRs bind type I TKI
edited	[InstanceEdit:9677035] Rothfels, Karen, 2020-02-25
eventOf	[Pathway:R-HSA-186797] Signaling by PDGF - Homo sapiens
input	[Complex:R-HSA-389079] PDGF alpha receptor: PDGF dimers [plasma membrane] [DefinedSet:R-ALL-9674075] type I PDGFR-binding tyrosine kinase inhibitors [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9674057] Pazopanib inhibits the activation of PDGFR?-expressing astrocytes in the brain metastatic microenvironment of breast cancer cells [LiteratureReference:9674032] Inhibition of the platelet-derived growth factor receptor beta (PDGFRB) using gene silencing, crenolanib besylate, or imatinib mesylate hampers the malignant phenotype of mesothelioma cell lines [LiteratureReference:9674068] The FLT3 and PDGFR inhibitor crenolanib is a substrate of the multidrug resistance protein ABCB1 but does not inhibit transport function at pharmacologically relevant concentrations [LiteratureReference:9674023] Crenolanib, a PDGFR inhibitor, suppresses lung cancer cell proliferation and inhibits tumor growth in vivo [LiteratureReference:9671319] A precision therapy against cancers driven by KIT/PDGFRA mutations [LiteratureReference:9671447] Structural and clinical consequences of activation loop mutations in class III receptor tyrosine kinases [LiteratureReference:9673583] The role of small molecule platelet-derived growth factor receptor (PDGFR) inhibitors in the treatment of neoplastic disorders
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	PDGFRs bind type I TKI
orthologousEvent	[Reaction:R-DME-9674093] PDGFRs bind type I TKI - Drosophila melanogaster [Reaction:R-CEL-9674093] PDGFRs bind type I TKI - Caenorhabditis elegans [Reaction:R-GGA-9674093] PDGFRs bind type I TKI - Gallus gallus [Reaction:R-DRE-9674093] PDGFRs bind type I TKI - Danio rerio [Reaction:R-SSC-9674093] PDGFRs bind type I TKI - Sus scrofa [Reaction:R-BTA-9674093] PDGFRs bind type I TKI - Bos taurus [Reaction:R-CFA-9674093] PDGFRs bind type I TKI - Canis familiaris [Reaction:R-RNO-9674093] PDGFRs bind type I TKI - Rattus norvegicus [Reaction:R-MMU-9674093] PDGFRs bind type I TKI - Mus musculus
output	[Complex:R-HSA-9674082] PDGFR:type I PDGFR-binding TKIs [plasma membrane]
releaseDate	2020-03-17
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9676030] Ip, Carman K M, 2020-02-06
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9674093
summation	[Summation:9674088] Wild-type PDGFRA and PDGFRB can be bound and inhibited by c...

Referrals

(normalReaction)	[Reaction:R-HSA-9674427] PDGFR mutants bind type I TKIs
(hasEvent)	[Pathway:R-HSA-186797] Signaling by PDGF

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