Wild-type PDGFRA and PDGFRB can be bound and inhibited by c...

created [InstanceEdit:9674089] Rothfels, Karen, 2020-01-10
dbId 9674088
displayName Wild-type PDGFRA and PDGFRB can be bound and inhibited by c...
modified [InstanceEdit:9676120] Rothfels, Karen, 2020-02-08
schemaClass Summation
text Wild-type PDGFRA and PDGFRB can be bound and inhibited by class I tyrosine kinase inhibitors including pazopanib, avapritinib, and crenolanib (Gril et al, 2013; Wang et al, 2014; Mathias et al, 2015; Meliau et al, 2017; reviewed in Klug et al, 2018). Type I inhibitors bind in the ATP binding site of the active conformation and prevent full activation of the kinase (reviewed in Roskoski, 2018).
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