Reactome | PDGFRs bind type I TKI

Schema > Reaction > Entries

category	binding
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10904201
displayName	PDGFRs bind type I TKI
eventOf	[Pathway:R-DME-186797] Signaling by PDGF - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-9674093] PDGFRs bind type I TKI - Homo sapiens
input	[Complex:R-DME-389079] PDGF alpha receptor: PDGF dimers [plasma membrane] [DefinedSet:R-ALL-9674075] type I PDGFR-binding tyrosine kinase inhibitors [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	PDGFRs bind type I TKI
output	[Complex:R-DME-9674082] PDGFR:type I PDGFR-binding TKIs [plasma membrane]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:56210] Drosophila melanogaster
stId	R-DME-9674093
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-DME-186797] Signaling by PDGF
(inferredTo)	[Reaction:R-HSA-9674093] PDGFRs bind type I TKI