Reactome | Ligand-independent dimerization of PDGFR mutants

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Ligand-independent dimerization of PDGFR mutants Show undefined attributes

authored	[InstanceEdit:9677035] Rothfels, Karen, 2020-02-25
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9672161] Rothfels, Karen, 2019-12-23
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	9672168
disease	[Disease:1500689] cancer
displayName	Ligand-independent dimerization of PDGFR mutants
edited	[InstanceEdit:9677035] Rothfels, Karen, 2020-02-25
entityFunctionalStatus	[EntityFunctionalStatus:9672155] gain_of_function of PDGFR mutant receptors [plasma membrane]
eventOf	[Pathway:R-HSA-9673767] Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants - Homo sapiens
followingEvent	[Reaction:R-HSA-9672175] Autophosphorylation of PDGFR mutant dimers - Homo sapiens
input	2 × [DefinedSet:R-HSA-9672123] PDGFR mutant receptors [plasma membrane]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9671898] PDGFRA activating mutations in gastrointestinal stromal tumors [LiteratureReference:9671911] PDGFRA mutations in gastrointestinal stromal tumors: frequency, spectrum and in vitro sensitivity to imatinib [LiteratureReference:9673515] Gain-of-function mutations of platelet-derived growth factor receptor alpha gene in gastrointestinal stromal tumors [LiteratureReference:9673583] The role of small molecule platelet-derived growth factor receptor (PDGFR) inhibitors in the treatment of neoplastic disorders [LiteratureReference:9671447] Structural and clinical consequences of activation loop mutations in class III receptor tyrosine kinases [LiteratureReference:9671907] PDGFRA alterations in cancer: characterization of a gain-of-function V536E transmembrane mutant as well as loss-of-function and passenger mutations [LiteratureReference:9676100] GEIS guidelines for gastrointestinal sarcomas (GIST) [LiteratureReference:9671886] Neomorphic PDGFRA extracellular domain driver mutations are resistant to PDGFRA targeted therapies
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Ligand-independent dimerization of PDGFR mutants
normalReaction	[BlackBoxEvent:R-HSA-186773] PDGF dimer binds two receptors simultaneously
output	[DefinedSet:R-HSA-9672131] PDGFR mutant dimers [plasma membrane]
releaseDate	2020-03-17
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9676030] Ip, Carman K M, 2020-02-06
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9672168
summation	[Summation:9673741] Activating missense and small in-frame deletion mutations in...

Referrals

(hasEvent)	[Pathway:R-HSA-9673767] Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants
(precedingEvent)	[Reaction:R-HSA-9672175] Autophosphorylation of PDGFR mutant dimers