Reactome | Autophosphorylation of PDGFR mutant dimers

Schema > Reaction > Entries

Autophosphorylation of PDGFR mutant dimers Show undefined attributes

authored	[InstanceEdit:9677035] Rothfels, Karen, 2020-02-25
catalystActivity	[CatalystActivity:9672169] protein tyrosine kinase activity of PDGFR mutant dimers [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:9672161] Rothfels, Karen, 2019-12-23
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	9672175
disease	[Disease:1500689] cancer
displayName	Autophosphorylation of PDGFR mutant dimers
edited	[InstanceEdit:9677035] Rothfels, Karen, 2020-02-25
entityFunctionalStatus	[EntityFunctionalStatus:9672147] gain_of_function of PDGFR mutant dimers [plasma membrane]
eventOf	[Pathway:R-HSA-9673767] Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants - Homo sapiens
followingEvent	[Reaction:R-HSA-9672164] GRB2:SOS1 complex binds to mutant PDGFR receptor - Homo sapiens [Reaction:R-HSA-9672176] STAT binds to the mutant PDGFRA receptor - Homo sapiens [Reaction:R-HSA-9672172] PI3-kinase binds to mutant PDGFR receptor - Homo sapiens
input	22 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [DefinedSet:R-HSA-9672131] PDGFR mutant dimers [plasma membrane]
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9671898] PDGFRA activating mutations in gastrointestinal stromal tumors [LiteratureReference:9671911] PDGFRA mutations in gastrointestinal stromal tumors: frequency, spectrum and in vitro sensitivity to imatinib [LiteratureReference:9673515] Gain-of-function mutations of platelet-derived growth factor receptor alpha gene in gastrointestinal stromal tumors [LiteratureReference:9671907] PDGFRA alterations in cancer: characterization of a gain-of-function V536E transmembrane mutant as well as loss-of-function and passenger mutations [LiteratureReference:9673583] The role of small molecule platelet-derived growth factor receptor (PDGFR) inhibitors in the treatment of neoplastic disorders [LiteratureReference:9671447] Structural and clinical consequences of activation loop mutations in class III receptor tyrosine kinases
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Autophosphorylation of PDGFR mutant dimers
normalReaction	[Reaction:R-HSA-389083] Autophosphorylation of PDGF alpha receptors
output	22 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [DefinedSet:R-HSA-9672040] p-11Y PDGFR mutant receptor dimers [plasma membrane]
precedingEvent	[Reaction:R-HSA-9672168] Ligand-independent dimerization of PDGFR mutants - Homo sapiens
releaseDate	2020-03-17
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9676030] Ip, Carman K M, 2020-02-06
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9672175
summation	[Summation:9673747] Activating mutations in the kinase, juxtamembrane and transm...

Referrals

(hasEvent)	[Pathway:R-HSA-9673767] Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants
(precedingEvent)	[Reaction:R-HSA-9672164] GRB2:SOS1 complex binds to mutant PDGFR receptor [Reaction:R-HSA-9672176] STAT binds to the mutant PDGFRA receptor [Reaction:R-HSA-9672172] PI3-kinase binds to mutant PDGFR receptor