Reactome | PDGF dimer binds two receptors simultaneously

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PDGF dimer binds two receptors simultaneously Show undefined attributes

authored	[InstanceEdit:382627] Garapati, P V, Jassal, B, 2008-11-24 10:14:27
category	omitted
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:186802] Jassal, B, 2006-08-15 13:51:10
dbId	186773
diseaseReaction	[Reaction:R-HSA-9672168] Ligand-independent dimerization of PDGFR mutants - Homo sapiens
displayName	PDGF dimer binds two receptors simultaneously
edited	[InstanceEdit:382627] Garapati, P V, Jassal, B, 2008-11-24 10:14:27
eventOf	[Pathway:R-HSA-186797] Signaling by PDGF - Homo sapiens
followingEvent	[Reaction:R-HSA-186786] Autophosphorylation of PDGF beta receptors - Homo sapiens [Reaction:R-HSA-389086] Autophosphorylation of PDGF alpha/beta receptors - Homo sapiens [Reaction:R-HSA-389083] Autophosphorylation of PDGF alpha receptors - Homo sapiens
input	[DefinedSet:R-HSA-380760] Active PDGF dimers (AA, AB, BB) [extracellular region] 2 × [DefinedSet:R-HSA-186792] PDGFRA, PDGFRB [plasma membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:380735] Signal transduction via platelet-derived growth factor receptors [LiteratureReference:9673583] The role of small molecule platelet-derived growth factor receptor (PDGFR) inhibitors in the treatment of neoplastic disorders [LiteratureReference:9674057] Pazopanib inhibits the activation of PDGFR?-expressing astrocytes in the brain metastatic microenvironment of breast cancer cells [LiteratureReference:9674032] Inhibition of the platelet-derived growth factor receptor beta (PDGFRB) using gene silencing, crenolanib besylate, or imatinib mesylate hampers the malignant phenotype of mesothelioma cell lines [LiteratureReference:9674068] The FLT3 and PDGFR inhibitor crenolanib is a substrate of the multidrug resistance protein ABCB1 but does not inhibit transport function at pharmacologically relevant concentrations [LiteratureReference:9674023] Crenolanib, a PDGFR inhibitor, suppresses lung cancer cell proliferation and inhibits tumor growth in vivo [LiteratureReference:9674200] Discovery of N-(2-chloro-6-methyl- phenyl)-2-(6-(4-(2-hydroxyethyl)- piperazin-1-yl)-2-methylpyrimidin-4- ylamino)thiazole-5-carboxamide (BMS-354825), a dual Src/Abl kinase inhibitor with potent antitumor activity in preclinical assays [LiteratureReference:9674255] Potent inhibition of platelet-derived growth factor-induced responses in vascular smooth muscle cells by BMS-354825 (dasatinib) [LiteratureReference:2077545] E7080, a novel inhibitor that targets multiple kinases, has potent antitumor activities against stem cell factor producing human small cell lung cancer H146, based on angiogenesis inhibition [LiteratureReference:9674254] Inhibition of PDGF, TGF-?, and Abl signaling and reduction of liver fibrosis by the small molecule Bcr-Abl tyrosine kinase antagonist Nilotinib [LiteratureReference:9674181] BIBF 1120: triple angiokinase inhibitor with sustained receptor blockade and good antitumor efficacy [LiteratureReference:9674295] Triple Angiokinase Inhibitor Nintedanib Directly Inhibits Tumor Cell Growth and Induces Tumor Shrinkage via Blocking Oncogenic Receptor Tyrosine Kinases [LiteratureReference:9674174] BAY 43-9006: preclinical data [LiteratureReference:9674258] Preclinical and clinical development of the oral multikinase inhibitor sorafenib in cancer treatment [LiteratureReference:9674233] In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: determination of a pharmacokinetic/pharmacodynamic relationship [LiteratureReference:9674288] Sunitinib: a VEGF and PDGF receptor protein kinase and angiogenesis inhibitor [LiteratureReference:9673974] Stromal platelet-derived growth factor receptor ? (PDGFR?) provides a therapeutic target independent of tumor cell PDGFR? expression in lung cancer xenografts [LiteratureReference:9673955] Autocrine activation of PDGFRalpha promotes the progression of ovarian cancer [LiteratureReference:9674003] Targeting the {alpha} receptor for platelet-derived growth factor as a primary or combination therapy in a preclinical model of prostate cancer skeletal metastasis [LiteratureReference:9673963] Platelet-derived growth factor receptor-alpha: a novel therapeutic target in human hepatocellular cancer
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	PDGF dimer binds two receptors simultaneously
orthologousEvent	[BlackBoxEvent:R-MMU-186773] PDGF dimer binds two receptors simultaneously - Mus musculus [BlackBoxEvent:R-RNO-186773] PDGF dimer binds two receptors simultaneously - Rattus norvegicus [BlackBoxEvent:R-CFA-186773] PDGF dimer binds two receptors simultaneously - Canis familiaris [BlackBoxEvent:R-BTA-186773] PDGF dimer binds two receptors simultaneously - Bos taurus [BlackBoxEvent:R-SSC-186773] PDGF dimer binds two receptors simultaneously - Sus scrofa [BlackBoxEvent:R-DRE-186773] PDGF dimer binds two receptors simultaneously - Danio rerio [BlackBoxEvent:R-XTR-186773] PDGF dimer binds two receptors simultaneously - Xenopus tropicalis [BlackBoxEvent:R-GGA-186773] PDGF dimer binds two receptors simultaneously - Gallus gallus [BlackBoxEvent:R-DME-186773] PDGF dimer binds two receptors simultaneously - Drosophila melanogaster [BlackBoxEvent:R-CEL-186773] PDGF dimer binds two receptors simultaneously - Caenorhabditis elegans
output	[Complex:R-HSA-186766] PDGF:PDGF receptor dimer [plasma membrane]
precedingEvent	[Reaction:R-HSA-186785] PDGF-AA clevage by Furin - Homo sapiens [Reaction:R-HSA-8865276] PDGF-AB clevage by Furin - Homo sapiens [Reaction:R-HSA-8865275] PDGF-BB clevage by Furin - Homo sapiens
regulatedBy	[NegativeRegulation:9674159] Negative regulation by 'PDGFR:type II PDGFR-binding TKIs [plasma membrane]' [NegativeRegulation:9674160] Negative regulation by 'PDGFRA:olaratumab [plasma membrane]'
releaseDate	2009-04-01
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:382617] Heldin, CH, 2008-11-23 19:29:34
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-186773
summation	[Summation:186777] PDGF dimer binds two receptors simultaneously. The receptors...
updateTrackers	[UpdateTracker:9777393] Update Tracker - [BlackBoxEvent:186773] PDGF dimer binds two receptors simultaneously - v72:[addLiteratureReference, addRegulator, modifyText]

Referrals

(precedingEvent)	[Reaction:R-HSA-186786] Autophosphorylation of PDGF beta receptors [Reaction:R-HSA-389086] Autophosphorylation of PDGF alpha/beta receptors [Reaction:R-HSA-389083] Autophosphorylation of PDGF alpha receptors
(hasEvent)	[Pathway:R-HSA-186797] Signaling by PDGF
(normalReaction)	[Reaction:R-HSA-9672168] Ligand-independent dimerization of PDGFR mutants
(updatedInstance)	[UpdateTracker:9777393] Update Tracker - [BlackBoxEvent:186773] PDGF dimer binds two receptors simultaneously - v72:[addLiteratureReference, addRegulator, modifyText]

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