Reactome | PDGFRA I843_D846del [plasma membrane]

Schema > EntityWithAccessionedSequence > Entries

compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-HSA-9672068] PDGFRA D843_846 del dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-9672068] PDGFRA D843_846 del dimer [plasma membrane] - Homo sapiens
created	[InstanceEdit:9671534] Rothfels, Karen, 2019-12-19
crossReference	[DatabaseIdentifier:12020834] Mondo:0011719 [DatabaseIdentifier:9671539] COSMIC:COSM12431 [DatabaseIdentifier:9671532] COSMIC:COSV57265238 [DatabaseIdentifier:9671553] COSMIC:COSM28028
dbId	9671537
disease	[Disease:1500689] cancer [Disease:9661830] gastrointestinal stromal tumor
displayName	PDGFRA I843_D846del [plasma membrane]
endCoordinate	1089
hasModifiedResidue	[FragmentDeletionModification:9671525] Deletion of residues 843 to 846
inDisease	true
maxDepth	1
memberOf	[DefinedSet:R-HSA-9672125] imatinib-resistant PDGFR mutants [plasma membrane] - Homo sapiens [CandidateSet:R-HSA-9672124] kinase domain mutants of PDGFRA [plasma membrane] - Homo sapiens
modified	[InstanceEdit:9832431] Orlic-Milacic, Marija, 2023-03-31
name	PDGFRA I843_D846del Alpha platelet-derived growth factor receptor PGDS_HUMAN
referenceEntity	[ReferenceGeneProduct:uniprot:P16234] UniProt:P16234 PDGFRA
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-9671537
startCoordinate	24
updateTrackers	[UpdateTracker:9905878] Update Tracker - [EntityWithAccessionedSequence:9671537] PDGFRA I843_D846del [plasma membrane] - v85:[modifyName]

(updatedInstance)	[UpdateTracker:9905878] Update Tracker - [EntityWithAccessionedSequence:9671537] PDGFRA I843_D846del [plasma membrane] - v85:[modifyName]
(hasMember)	[DefinedSet:R-HSA-9672125] imatinib-resistant PDGFR mutants [plasma membrane] [CandidateSet:R-HSA-9672124] kinase domain mutants of PDGFRA [plasma membrane]
(hasComponent)	[Complex:R-HSA-9672068] PDGFRA D843_846 del dimer [plasma membrane]

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