Reactome | PDGFRA D842_M844del [plasma membrane]

Schema > EntityWithAccessionedSequence > Entries

compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-HSA-9672046] PDGFRA D842_M844del dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-9672046] PDGFRA D842_M844del dimer [plasma membrane] - Homo sapiens
created	[InstanceEdit:9671534] Rothfels, Karen, 2019-12-19
crossReference	[DatabaseIdentifier:12020834] Mondo:0011719 [DatabaseIdentifier:9671536] COSMIC:COSV57269877 [DatabaseIdentifier:9671544] COSMIC:COSV57266334 [DatabaseIdentifier:9750518] COSMIC:COSM19125
dbId	9671526
disease	[Disease:1500689] cancer [Disease:9661830] gastrointestinal stromal tumor
displayName	PDGFRA D842_M844del [plasma membrane]
endCoordinate	1089
hasModifiedResidue	[FragmentDeletionModification:9671554] Deletion of residues 842 to 844
inDisease	true
maxDepth	1
memberOf	[DefinedSet:R-HSA-9672125] imatinib-resistant PDGFR mutants [plasma membrane] - Homo sapiens [CandidateSet:R-HSA-9672124] kinase domain mutants of PDGFRA [plasma membrane] - Homo sapiens
modified	[InstanceEdit:9750522] Orlic-Milacic, Marija, 2021-08-13
name	PDGFRA D842_M844del Alpha platelet-derived growth factor receptor PGDS_HUMAN
referenceEntity	[ReferenceGeneProduct:uniprot:P16234] UniProt:P16234 PDGFRA
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-9671526
startCoordinate	24

(hasMember)	[DefinedSet:R-HSA-9672125] imatinib-resistant PDGFR mutants [plasma membrane] [CandidateSet:R-HSA-9672124] kinase domain mutants of PDGFRA [plasma membrane]
(hasComponent)	[Complex:R-HSA-9672046] PDGFRA D842_M844del dimer [plasma membrane]

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