KIT mutants:PI3K catalyze synthesis of PIP3

Stable Identifier
Reaction [transition]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
PI3K/AKT signaling is initiated downstream of KIT juxtamembrane and kinase domain mutants, as assessed by the presence of phosphorylated AKT in Western analysis (Kemmer et al, 2004; Nakai et al, 2005; Duensing et al, 2004; Tarn et al, 2006; Rossi et al, 2006; Bauer et al, 2007; Bosbach et al, 2017; Zhu et sl, 2007; Serrano et al, 2019; reviewed in Lennartsson and Roonstrand, 2012).
Literature References
PubMed ID Title Journal Year
23073628 Stem cell factor receptor/c-Kit: from basic science to clinical implications

Rönnstrand, L, Lennartsson, J

Physiol. Rev. 2012
14695343 KIT mutations are common in testicular seminomas

McGreevey, L, Corless, CL, Fletcher, JA, Kemmer, K, Heinrich, MC, Cummings, OW, Town, A, Haley, A, Griffith, D, Wait, C

Am. J. Pathol. 2004
16707477 Therapeutic effect of imatinib in gastrointestinal stromal tumors: AKT signaling dependent and independent mechanisms

Eisenberg, B, Tarn, C, Godwin, AK, Skorobogatko, YV, von Mehren, M, Taguchi, T

Cancer Res. 2006
15007386 Mechanisms of oncogenic KIT signal transduction in primary gastrointestinal stromal tumors (GISTs)

McConarty, B, Medeiros, F, Fletcher, JA, Demetri, GD, Singer, S, Fletcher, CD, Panigrahy, D, Joseph, NE, Duensing, A

Oncogene 2004
16188233 KIT (c-kit oncogene product) pathway is constitutively activated in human testicular germ cell tumors

Nakai, Y, Miki, T, Inoue, H, Oka, D, Mizutani, Y, Nakayama, M, Okuyama, A, Nonomura, N, Shiba, M, Arai, Y, Nishimura, K, Aozasa, K

Biochem. Biophys. Res. Commun. 2005
30792533 Complementary activity of tyrosine kinase inhibitors against secondary kit mutations in imatinib-resistant gastrointestinal stromal tumours

Heinrich, MC, Ketzer, J, Bauer, S, Zhu, M, Presnell, A, Raut, CP, George, S, Mannan, AM, Serrano, C, Yu, C, Sicinska, E, Tao, DL, Rubin, BP, Fletcher, JA, Mariño-Enríquez, A, Demetri, GD, Eilers, G, Czaplinski, JT, McKinley, A

Br. J. Cancer 2019
28923937 Direct engagement of the PI3K pathway by mutant KIT dominates oncogenic signaling in gastrointestinal stromal tumor

Antonescu, CR, Veach, D, Ehlers, I, Yozgat, Y, Warpinski, K, Besmer, P, Zhang, JQ, Kwok, A, Bosbach, B, Loo, J, Berrozpe, G, Rossi, F, Manova, K, DeMatteo, RP

Proc. Natl. Acad. Sci. U.S.A. 2017
17546049 KIT oncogenic signaling mechanisms in imatinib-resistant gastrointestinal stromal tumor: PI3-kinase/AKT is a crucial survival pathway

Demetri, GD, Bauer, S, Fletcher, JA, Duensing, A

Oncogene 2007
Catalyst Activity

1-phosphatidylinositol-3-kinase activity of PI3K:p-KIT mutant dimers [plasma membrane]

Normal reaction
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Cross References
Cite Us!