Reactome | Phosphorylated KIT mutants bind PI3K

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Phosphorylated KIT mutants bind PI3K Show undefined attributes

authored	[InstanceEdit:9681395] Rothfels, Karen, 2020-04-01
category	binding
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:9670432] Rothfels, Karen, 2019-12-09
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	9670431
disease	[Disease:1500689] cancer
displayName	Phosphorylated KIT mutants bind PI3K
edited	[InstanceEdit:9686618] Rothfels, Karen, 2020-05-04
entityFunctionalStatus	[EntityFunctionalStatus:9670402] gain_of_function of p7Y-KIT kinase, extracellular and juxtamembrane domain dimers [plasma membrane]
eventOf	[Pathway:R-HSA-9670439] Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants - Homo sapiens
followingEvent	[Reaction:R-HSA-9670433] KIT mutants:PI3K catalyze synthesis of PIP3 - Homo sapiens
input	[DefinedSet:R-HSA-9670355] p7Y-KIT kinase, extracellular and juxtamembrane domain dimers [plasma membrane] [Complex:R-HSA-198379] PI3K alpha [cytosol]
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9669213] KIT mutations are common in testicular seminomas [LiteratureReference:9669177] KIT (c-kit oncogene product) pathway is constitutively activated in human testicular germ cell tumors [LiteratureReference:9670489] M-COPA suppresses endolysosomal Kit-Akt oncogenic signalling through inhibiting the secretory pathway in neoplastic mast cells [LiteratureReference:9670495] Oncogenic signaling by Kit tyrosine kinase occurs selectively on the Golgi apparatus in gastrointestinal stromal tumors [LiteratureReference:9680542] Therapeutic effect of imatinib in gastrointestinal stromal tumors: AKT signaling dependent and independent mechanisms [LiteratureReference:9680533] Oncogenic Kit signaling and therapeutic intervention in a mouse model of gastrointestinal stromal tumor [LiteratureReference:9680307] KIT oncogenic signaling mechanisms in imatinib-resistant gastrointestinal stromal tumor: PI3-kinase/AKT is a crucial survival pathway [LiteratureReference:9680290] Direct engagement of the PI3K pathway by mutant KIT dominates oncogenic signaling in gastrointestinal stromal tumor [LiteratureReference:9680518] KIT oncoprotein interactions in gastrointestinal stromal tumors: therapeutic relevance [LiteratureReference:9673518] Gastrointestinal stromal tumours: origin and molecular oncology [LiteratureReference:9669245] Stem cell factor receptor/c-Kit: from basic science to clinical implications
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Phosphorylated KIT mutants bind PI3K
normalReaction	[Reaction:R-HSA-205262] Direct recruitment of PI3K to p-KIT
output	[Complex:R-HSA-9670376] PI3K:p-KIT mutant dimers [plasma membrane]
precedingEvent	[Reaction:R-HSA-9669890] Constitutive phosphorylation of kinase domain KIT mutants - Homo sapiens [Reaction:R-HSA-9669911] Phosphorylation of juxtamembrane domain KIT mutants - Homo sapiens
releaseDate	2020-06-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9678239] Serrano, C�sar, 2020-03-13 [InstanceEdit:9678232] Garc�a-Valverde, Alfonso, 2020-03-13 [InstanceEdit:9678237] Pilco-Janeta, Daniel, 2020-03-13
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9670431
summation	[Summation:9670513] PI3K-mediated signaling has been demonstrated downstream of ...

Referrals

(hasEvent)	[Pathway:R-HSA-9670439] Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants
(precedingEvent)	[Reaction:R-HSA-9670433] KIT mutants:PI3K catalyze synthesis of PIP3

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