Reactome | p7Y-KIT kinase, extracellular and juxtamembrane domain dimers [plasma membrane]

Schema > DefinedSet > Entries

compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-HSA-9670365] p-KIT mutants:GRB2:SOS [plasma membrane] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-9670428] KIT mutants bind GRB2-SOS - Homo sapiens [Reaction:R-HSA-9670431] Phosphorylated KIT mutants bind PI3K - Homo sapiens [Reaction:R-HSA-9670414] KIT mutants bind SFKs - Homo sapiens
created	[InstanceEdit:9670354] Rothfels, Karen, 2019-12-09
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	9670355
disease	[Disease:1500689] cancer
displayName	p7Y-KIT kinase, extracellular and juxtamembrane domain dimers [plasma membrane]
hasMember	[CandidateSet:R-HSA-9669816] p7Y-juxtamembrane domain KIT mutant dimers [plasma membrane] - Homo sapiens [CandidateSet:R-HSA-9669820] p7Y-kinase domain KIT mutants [plasma membrane] - Homo sapiens [CandidateSet:R-HSA-9680192] p7Y-extracellular domain mutants of KIT [plasma membrane] - Homo sapiens
inDisease	true
maxDepth	4
modified	[InstanceEdit:9680285] Rothfels, Karen, 2020-03-26
name	p7Y-KIT kinase, extracellular and juxtamembrane domain dimers
schemaClass	DefinedSet
species	[Species:48887] Homo sapiens
stId	R-HSA-9670355

(input)	[Reaction:R-HSA-9670428] KIT mutants bind GRB2-SOS [Reaction:R-HSA-9670431] Phosphorylated KIT mutants bind PI3K [Reaction:R-HSA-9670414] KIT mutants bind SFKs
(hasComponent)	[Complex:R-HSA-9670365] p-KIT mutants:GRB2:SOS [plasma membrane] [Complex:R-HSA-9670376] PI3K:p-KIT mutant dimers [plasma membrane] [Complex:R-HSA-9670368] KIT mutant dimers:SFKs [plasma membrane] [Complex:R-HSA-9670384] KIT mutant dimers:SFKs:JAK2 [plasma membrane]
(diseaseEntity)	[EntityFunctionalStatus:9670402] gain_of_function of p7Y-KIT kinase, extracellular and juxtamembrane domain dimers [plasma membrane]

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