Reactome | Phosphorylation of JAK2 downstream of KIT mutants

Schema > Reaction > Entries

Phosphorylation of JAK2 downstream of KIT mutants Show undefined attributes

authored	[InstanceEdit:9681395] Rothfels, Karen, 2020-04-01
catalystActivity	[CatalystActivity:9670409] protein tyrosine kinase activity of KIT mutant dimers:SFKs:JAK2 [plasma membrane]
catalystActivityReference	[CatalystActivityReference:9643310] protein tyrosine kinase activity of JAK2:SFKS:p-KIT complex [plasma membrane] Activation of Jak2 catalytic activity requires phosphorylation of Y1007 in the kinase activation loop
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:9670415] Rothfels, Karen, 2019-12-09
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	9670418
disease	[Disease:1500689] cancer
displayName	Phosphorylation of JAK2 downstream of KIT mutants
edited	[InstanceEdit:9686618] Rothfels, Karen, 2020-05-04
entityFunctionalStatus	[EntityFunctionalStatus:9670388] gain_of_function of KIT mutant dimers:SFKs:JAK2 [plasma membrane]
eventOf	[Pathway:R-HSA-9670439] Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants - Homo sapiens
followingEvent	[Reaction:R-HSA-9670416] Recruitment of STATs by KIT mutants - Homo sapiens
input	2 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-9670384] KIT mutant dimers:SFKs:JAK2 [plasma membrane]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:1433426] STAT protein recruitment and activation in c-Kit deletion mutants [LiteratureReference:9670498] Signal transducer and activator of transcription 3 activation is required for Asp(816) mutant c-Kit-mediated cytokine-independent survival and proliferation in human leukemia cells [LiteratureReference:9669122] Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors [LiteratureReference:9669245] Stem cell factor receptor/c-Kit: from basic science to clinical implications
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Phosphorylation of JAK2 downstream of KIT mutants
normalReaction	[Reaction:R-HSA-1433418] Phosphorylation of JAK2
output	2 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-HSA-9670380] KIT mutant dimers:SFKs:p-JAK2 [plasma membrane]
precedingEvent	[Reaction:R-HSA-9670413] JAK2 binds to p-KIT mutants - Homo sapiens
releaseDate	2020-06-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9678232] Garc�a-Valverde, Alfonso, 2020-03-13 [InstanceEdit:9678239] Serrano, C�sar, 2020-03-13 [InstanceEdit:9678237] Pilco-Janeta, Daniel, 2020-03-13
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9670418
summation	[Summation:9680550] Although the details haven't been examined in detail in all ...

Referrals

(precedingEvent)	[Reaction:R-HSA-9670416] Recruitment of STATs by KIT mutants
(hasEvent)	[Pathway:R-HSA-9670439] Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants

Cite Us!