Phosphorylation of JAK2 downstream of KIT mutants

Stable Identifier
Reaction [transition]
Homo sapiens
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Although the details haven't been examined in detail in all cases, phosphorylation of JAK2 likely occurs downstream of oncogenic mutations of KIT, as is the case for the wild-type receptor (Brizzi et al, 1999; Ning et al, 2001; Hirota et al, 1998; reviewed in Lennartsson and Roonstrand, 2012).

Literature References
PubMed ID Title Journal Year
23073628 Stem cell factor receptor/c-Kit: from basic science to clinical implications

Rönnstrand, L, Lennartsson, J

Physiol. Rev. 2012
10358045 STAT protein recruitment and activation in c-Kit deletion mutants

Yarden, Y, Dentelli, P, Pegoraro, L, Rosso, A, Brizzi, MF

J Biol Chem 1999
9438854 Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors

Kitamura, Y, Muhammad Tunio, G, Kanakura, Y, Matsuzawa, Y, Hanada, M, Moriyama, Y, Isozaki, K, Nishida, T, Hashimoto, K, Ishiguro, S, Kawano, K, Takeda, M, Kurata, A, Hirota, S, Shinomura, Y

Science 1998
11369651 Signal transducer and activator of transcription 3 activation is required for Asp(816) mutant c-Kit-mediated cytokine-independent survival and proliferation in human leukemia cells

Arceci, RJ, Li, J, Ning, ZQ

Blood 2001
Catalyst Activity

protein tyrosine kinase activity of KIT mutant dimers:SFKs:JAK2 [plasma membrane]

Normal reaction
Functional status

Gain of function of KIT mutant dimers:SFKs:JAK2 [plasma membrane]

Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
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