Reactome | protein tyrosine kinase activity of JAK2:SFKS:p-KIT complex [plasma membrane] Activation of Jak2 catalytic activity requires phosphorylation of Y1007 in the kinase activation loop

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catalystActivity	[CatalystActivity:2447206] protein tyrosine kinase activity of JAK2:SFKS:p-KIT complex [plasma membrane]
created	[InstanceEdit:9643047] Wu, G, 2019-04-04
dbId	9643310
displayName	protein tyrosine kinase activity of JAK2:SFKS:p-KIT complex [plasma membrane] Activation of Jak2 catalytic activity requires phosphorylation of Y1007 in the kinase activation loop
literatureReference	[LiteratureReference:873856] Activation of Jak2 catalytic activity requires phosphorylation of Y1007 in the kinase activation loop [LiteratureReference:873860] Autophosphorylation of JAK2 on tyrosines 221 and 570 regulates its activity [LiteratureReference:873836] Tyrosines 868, 966, and 972 in the kinase domain of JAK2 are autophosphorylated and required for maximal JAK2 kinase activity
schemaClass	CatalystActivityReference

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