Reactome | Recruitment of STATs by KIT mutants

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Recruitment of STATs by KIT mutants Show undefined attributes

authored	[InstanceEdit:9681395] Rothfels, Karen, 2020-04-01
category	binding
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:9670415] Rothfels, Karen, 2019-12-09
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	9670416
disease	[Disease:1500689] cancer
displayName	Recruitment of STATs by KIT mutants
edited	[InstanceEdit:9686618] Rothfels, Karen, 2020-05-04
entityFunctionalStatus	[EntityFunctionalStatus:9670390] gain_of_function of KIT mutant dimers:SFKs:p-JAK2 [plasma membrane]
eventOf	[Pathway:R-HSA-9670439] Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9670412] Phosphorylation of STATs downstream of KIT mutants - Homo sapiens
input	[Complex:R-HSA-9670380] KIT mutant dimers:SFKs:p-JAK2 [plasma membrane] 2 × [DefinedSet:R-HSA-1433551] STATs [cytosol]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:1433426] STAT protein recruitment and activation in c-Kit deletion mutants [LiteratureReference:9670498] Signal transducer and activator of transcription 3 activation is required for Asp(816) mutant c-Kit-mediated cytokine-independent survival and proliferation in human leukemia cells [LiteratureReference:9670475] Juxtamembrane mutant V560GKit is more sensitive to Imatinib (STI571) compared with wild-type c-kit whereas the kinase domain mutant D816VKit is resistant [LiteratureReference:9669059] Activation mutations of human c-KIT resistant to imatinib mesylate are sensitive to the tyrosine kinase inhibitor PKC412 [LiteratureReference:9670489] M-COPA suppresses endolysosomal Kit-Akt oncogenic signalling through inhibiting the secretory pathway in neoplastic mast cells [LiteratureReference:9670495] Oncogenic signaling by Kit tyrosine kinase occurs selectively on the Golgi apparatus in gastrointestinal stromal tumors [LiteratureReference:9680303] Mechanisms of oncogenic KIT signal transduction in primary gastrointestinal stromal tumors (GISTs) [LiteratureReference:9680307] KIT oncogenic signaling mechanisms in imatinib-resistant gastrointestinal stromal tumor: PI3-kinase/AKT is a crucial survival pathway [LiteratureReference:1433411] Stat1 associates with c-kit and is activated in response to stem cell factor [LiteratureReference:1433283] Signal transduction via the stem cell factor receptor/c-Kit [LiteratureReference:9669245] Stem cell factor receptor/c-Kit: from basic science to clinical implications
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Recruitment of STATs by KIT mutants
normalReaction	[Reaction:R-HSA-1433456] Recruitment of STATs
output	[Complex:R-HSA-9670379] KIT mutant dimers:SFKs:p-JAK2:STATs [plasma membrane]
precedingEvent	[Reaction:R-HSA-9670418] Phosphorylation of JAK2 downstream of KIT mutants - Homo sapiens
releaseDate	2020-06-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9678239] Serrano, C�sar, 2020-03-13 [InstanceEdit:9678232] Garc�a-Valverde, Alfonso, 2020-03-13 [InstanceEdit:9678237] Pilco-Janeta, Daniel, 2020-03-13
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9670416
summation	[Summation:9680610] Extracellular- , juxtamembrane- and kinase-domain mutants of...

Referrals

(hasEvent)	[Pathway:R-HSA-9670439] Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants
(precedingEvent)	[BlackBoxEvent:R-HSA-9670412] Phosphorylation of STATs downstream of KIT mutants

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