Reactome | p7Y-extracellular domain mutants of KIT [plasma membrane]

Schema > CandidateSet > Entries

p7Y-extracellular domain mutants of KIT [plasma membrane] Show undefined attributes

compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9680193] Rothfels, Karen, 2020-03-25
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	9680192
disease	[Disease:1500689] cancer
displayName	p7Y-extracellular domain mutants of KIT [plasma membrane]
hasCandidate	[Complex:R-HSA-9680133] p7Y-KIT C443S dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-9680131] p7Y-KIT D419G dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-9680140] p7Y-KIT D419H dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-9680139] p7Y-KIT D419N dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-9680136] p7Y-KIT D419del dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-9680155] p7Y-KIT N505_F508dup dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-9680160] p7Y-KIT S476N dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-9680157] p7Y-KIT S501_A502dup dimer [plasma membrane] - Homo sapiens
hasMember	[Complex:R-HSA-9680123] p7Y-KIT A502_Y503dup dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-9680135] p7Y-KIT C443Y dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-9680128] p7Y-KIT D419A dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-9680189] p7Y-KIT K509I dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-9680164] p7Y-KIT S476I dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-9680163] p7Y-KIT T417-D419delinsY dimer [plasma membrane] - Homo sapiens
inDisease	true
literatureReference	[LiteratureReference:9679992] Extracellular KIT receptor mutants, commonly found in core binding factor AML, are constitutively active and respond to imatinib mesylate [LiteratureReference:9679981] Pediatric mastocytosis is a clonal disease associated with D816V and other activating c-KIT mutations
maxDepth	3
memberOf	[DefinedSet:R-HSA-9670355] p7Y-KIT kinase, extracellular and juxtamembrane domain dimers [plasma membrane] - Homo sapiens
modified	[InstanceEdit:9680284] Rothfels, Karen, 2020-03-26
name	p7Y-extracellular domain mutants of KIT
producedByEvent	[Reaction:R-HSA-9680248] Phosphorylation of extracellular domain KIT mutants - Homo sapiens
schemaClass	CandidateSet
species	[Species:48887] Homo sapiens
stId	R-HSA-9680192

Referrals

(output)	[Reaction:R-HSA-9680248] Phosphorylation of extracellular domain KIT mutants
(hasMember)	[DefinedSet:R-HSA-9670355] p7Y-KIT kinase, extracellular and juxtamembrane domain dimers [plasma membrane]

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