Reactome | KIT D820A [plasma membrane]

Schema > EntityWithAccessionedSequence > Entries

compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9669459] Rothfels, Karen, 2019-12-03
crossReference	[DatabaseIdentifier:12020834] Mondo:0011719 [DatabaseIdentifier:9669316] COSMIC:COSM28999 [DatabaseIdentifier:9669352] COSMIC:COSV55405326
dbId	9669460
disease	[Disease:1500689] cancer [Disease:9661830] gastrointestinal stromal tumor
displayName	KIT D820A [plasma membrane]
endCoordinate	976
hasModifiedResidue	[ReplacedResidue:9669465] L-aspartic acid 820 replaced with L-alanine
inDisease	true
maxDepth	1
memberOf	[DefinedSet:R-HSA-9669838] sunitinib resistant KIT mutants [plasma membrane] - Homo sapiens [DefinedSet:R-HSA-9669735] dasatinib sensitive KIT mutants [plasma membrane] - Homo sapiens [DefinedSet:R-HSA-9669748] imatinib resistant KIT mutants [plasma membrane] - Homo sapiens [CandidateSet:R-HSA-9681384] ripretinib-sensitive KIT mutants [plasma membrane] - Homo sapiens [DefinedSet:R-HSA-9669822] ponatinib sensitive KIT mutants [plasma membrane] - Homo sapiens [DefinedSet:R-HSA-9669825] regorafenib sensitive KIT mutants [plasma membrane] - Homo sapiens
name	KIT D820A Mast/stem cell growth factor receptor precursor KIT_HUMAN c-KIT
referenceEntity	[ReferenceGeneProduct:uniprot:P10721] UniProt:P10721 KIT
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-9669460
startCoordinate	26

(hasMember)