Reactome | ripretinib-sensitive KIT mutants [plasma membrane]

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ripretinib-sensitive KIT mutants [plasma membrane] Show undefined attributes

compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-HSA-9681383] ripretinib-sensitive KIT:ripretinib [plasma membrane] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-9681382] KIT mutants bind ripretinib - Homo sapiens
created	[InstanceEdit:9681381] Rothfels, Karen, 2020-04-01
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	9681384
disease	[Disease:1500689] cancer
displayName	ripretinib-sensitive KIT mutants [plasma membrane]
hasCandidate	[EntityWithAccessionedSequence:R-HSA-9669428] KIT D816A [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9669436] KIT D816E [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9669451] KIT D816N [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9669468] KIT K642Q [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9669453] KIT N822I [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9669466] KIT N822S [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9669566] KIT V560E [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9669569] KIT V560G [plasma membrane] - Homo sapiens
hasMember	[EntityWithAccessionedSequence:R-HSA-9680030] KIT A502_Y503dup [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9669457] KIT D816F [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9669445] KIT D816H [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9669452] KIT D816V [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9669435] KIT D816Y [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9669460] KIT D820A [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9669449] KIT D820E [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9669443] KIT K642E [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9669437] KIT N822H [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9669464] KIT N822K [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9669463] KIT N822T [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9669454] KIT N822Y [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9669545] KIT T670I [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9669564] KIT V560D [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9669572] KIT V654A [plasma membrane] - Homo sapiens
inDisease	true
literatureReference	[LiteratureReference:9674274] Ripretinib (DCC-2618) Is a Switch Control Kinase Inhibitor of a Broad Spectrum of Oncogenic and Drug-Resistant KIT and PDGFRA Variants
maxDepth	2
name	ripretinib-sensitive KIT mutants
schemaClass	CandidateSet
species	[Species:48887] Homo sapiens
stId	R-HSA-9681384

Referrals

(hasComponent)	[Complex:R-HSA-9681383] ripretinib-sensitive KIT:ripretinib [plasma membrane]
(input)	[Reaction:R-HSA-9681382] KIT mutants bind ripretinib
(diseaseEntity)	[EntityFunctionalStatus:9686617] gain_of_function of ripretinib-sensitive KIT mutants [plasma membrane]

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