Reactome | nilotinib resistant KIT mutants [plasma membrane]

Schema > DefinedSet > Entries

compartment	[Compartment:876] plasma membrane
consumedByEvent	[FailedReaction:R-HSA-9669868] Nilotinib-resistant KIT mutants do not bind nilotinib - Homo sapiens
created	[InstanceEdit:9669771] Rothfels, Karen, 2019-12-03
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	9669772
disease	[Disease:1500689] cancer
displayName	nilotinib resistant KIT mutants [plasma membrane]
hasMember	[EntityWithAccessionedSequence:R-HSA-9669426] KIT A829P [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9669436] KIT D816E [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9669460] KIT D820A [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9669545] KIT T670I [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9669572] KIT V654A [plasma membrane] - Homo sapiens
inDisease	true
literatureReference	[LiteratureReference:9671438] Sorafenib inhibits the imatinib-resistant KITT670I gatekeeper mutation in gastrointestinal stromal tumor [LiteratureReference:9671417] Resistance to c-KIT kinase inhibitors conferred by V654A mutation [LiteratureReference:9669094] Complementary activity of tyrosine kinase inhibitors against secondary kit mutations in imatinib-resistant gastrointestinal stromal tumours
maxDepth	2
modified	[InstanceEdit:9671502] Rothfels, Karen, 2019-12-19
name	nilotinib resistant KIT mutants
schemaClass	DefinedSet
species	[Species:48887] Homo sapiens
stId	R-HSA-9669772

(input)	[FailedReaction:R-HSA-9669868] Nilotinib-resistant KIT mutants do not bind nilotinib
(diseaseEntity)	[EntityFunctionalStatus:9669866] loss_of_function of nilotinib resistant KIT mutants [plasma membrane]