Reactome | ERBB2 binds pertuzumab

Schema > Reaction > Entries

authored	[InstanceEdit:9665478] Orlic-Milacic, Marija, 2019-10-31
category	binding
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:9665727] Orlic-Milacic, Marija, 2019-10-31
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	9665726
disease	[Disease:1500689] cancer
diseaseReaction	[FailedReaction:R-HSA-9665708] ERBB2 TMD/JMD mutants do not bind pertuzumab - Homo sapiens [Reaction:R-HSA-9665703] ERBB2 TMD/JMD mutants bind pertuzumab - Homo sapiens
displayName	ERBB2 binds pertuzumab
edited	[InstanceEdit:9665760] Orlic-Milacic, Marija, 2019-11-01
eventOf	[Pathway:R-HSA-9652282] Drug-mediated inhibition of ERBB2 signaling - Homo sapiens
input	[Complex:R-HSA-1227970] ERBB2:ERBIN:HSP90:CDC37 [plasma membrane] [ProteinDrug:R-ALL-9665971] pertuzumab [extracellular region]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9665988] Insights into ErbB signaling from the structure of the ErbB2-pertuzumab complex
maxDepth	1
modified	[InstanceEdit:9866055] Orlic-Milacic, Marija, 2024-03-20
name	ERBB2 binds pertuzumab
output	[Complex:R-HSA-9665974] ERBB2:pertuzumab:ERBIN:HSP90:CDC37 [plasma membrane]
releaseDate	2019-12-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9666741] Kancha, Rama Krishna, 2019-11-03
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9665726
summation	[Summation:9665990] Pertuzumab is an ERBB2-directed therapeutic antibody that bi...

(normalReaction)	[FailedReaction:R-HSA-9665708] ERBB2 TMD/JMD mutants do not bind pertuzumab [Reaction:R-HSA-9665703] ERBB2 TMD/JMD mutants bind pertuzumab
(hasEvent)	[Pathway:R-HSA-9652282] Drug-mediated inhibition of ERBB2 signaling

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