ERBB2 binds pertuzumab

Stable Identifier
R-HSA-9665726
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region, plasma membrane
ReviewStatus
5/5
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ERBB2 binds pertuzumab
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Pertuzumab is an ERBB2-directed therapeutic antibody that binds to ERBB2 and sterically blocks receptor dimerization and signaling (Franklin et al. 2004).

Literature References
PubMed ID Title Journal Year
15093539 Insights into ErbB signaling from the structure of the ErbB2-pertuzumab complex

Sliwkowski, MX, Leahy, DJ, Vajdos, FF, de Vos, AM, Carey, KD, Franklin, MC

Cancer Cell 2004
Participants
Input
Output
Participates
as an event of
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Authored
Orlic-Milacic, M  (2019-10-31)
Reviewed
Kancha, RK  (2019-11-03)
Created
Orlic-Milacic, M  (2019-10-31)
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