Reactome | ERBB2:ERBIN:HSP90:CDC37 [plasma membrane]

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ERBB2:ERBIN:HSP90:CDC37 [plasma membrane] Show undefined attributes

compartment	[Compartment:876] plasma membrane
consumedByEvent	[Reaction:R-HSA-1227964] ERBB2 homodimerization - Homo sapiens [Reaction:R-HSA-1227964] ERBB2 homodimerization - Homo sapiens [Reaction:R-HSA-1918095] CUL5 mediates ubiquitination of ERBB2 - Homo sapiens [Reaction:R-HSA-1918092] CHIP (STUB1) mediates ubiquitination of ERBB2 - Homo sapiens [Reaction:R-HSA-9665726] ERBB2 binds pertuzumab - Homo sapiens [Reaction:R-HSA-9652264] ERBB2 binds TKIs - Homo sapiens [Reaction:R-HSA-9652277] ERBB2 binds trastuzumab - Homo sapiens [Reaction:R-HSA-1963589] ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4 - Homo sapiens [Reaction:R-HSA-1963589] ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4 - Homo sapiens [Reaction:R-HSA-1963589] ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4 - Homo sapiens [Reaction:R-HSA-1963589] ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4 - Homo sapiens
created	[InstanceEdit:1227968] Orlic-Milacic, Marija, 2011-03-14
dbId	1227970
displayName	ERBB2:ERBIN:HSP90:CDC37 [plasma membrane]
hasComponent	[Complex:R-HSA-1225828] CDC37 [cytosol] [EntityWithAccessionedSequence:R-HSA-372889] ERBB2 [plasma membrane] [EntityWithAccessionedSequence:R-HSA-1358718] ERBIN [plasma membrane] [Complex:R-HSA-1221657] HSP90 [cytosol]
inDisease	false
includedLocation	[Compartment:70101] cytosol
inferredTo	[Complex:R-MMU-1227970] ERBB2:ERBIN:HSP90:CDC37 [plasma membrane] - Mus musculus [Complex:R-RNO-1227970] ERBB2:ERBIN:HSP90:CDC37 [plasma membrane] - Rattus norvegicus [Complex:R-CFA-1227970] ERBB2:ERBIN:HSP90:CDC37 [plasma membrane] - Canis familiaris [Complex:R-BTA-1227970] ERBB2:ERBIN:HSP90:CDC37 [plasma membrane] - Bos taurus [Complex:R-SSC-1227970] ERBB2:ERBIN:HSP90:CDC37 [plasma membrane] - Sus scrofa [Complex:R-DRE-1227970] ERBB2:ERBIN:HSP90:CDC37 [plasma membrane] - Danio rerio [Complex:R-GGA-1227970] ERBB2:ERBIN:HSP90:CDC37 [plasma membrane] - Gallus gallus [Complex:R-DME-1227970] ERBB2:ERBIN:HSP90:CDC37 [plasma membrane] - Drosophila melanogaster [Complex:R-CEL-1227970] ERBB2:ERBIN:HSP90:CDC37 [plasma membrane] - Caenorhabditis elegans [Complex:R-SPO-1227970] ERBB2:ERBIN:HSP90:CDC37 [plasma membrane] - Schizosaccharomyces pombe
isChimeric	false
maxDepth	3
modified	[InstanceEdit:9646486] Orlic-Milacic, Marija, 2019-05-24
name	ERBB2:ERBIN:HSP90:CDC37
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-1227970
updateTrackers	[UpdateTracker:9872093] Update Tracker - [Complex:1227970] ERBB2:ERBIN:HSP90:CDC37 [plasma membrane] - v41:[removeCompartment] [UpdateTracker:9900855] Update Tracker - [Complex:1227970] ERBB2:ERBIN:HSP90:CDC37 [plasma membrane] - v70:[modifyName]

Referrals

(updatedInstance)	[UpdateTracker:9872093] Update Tracker - [Complex:1227970] ERBB2:ERBIN:HSP90:CDC37 [plasma membrane] - v41:[removeCompartment] [UpdateTracker:9900855] Update Tracker - [Complex:1227970] ERBB2:ERBIN:HSP90:CDC37 [plasma membrane] - v70:[modifyName]
(input)	[Reaction:R-HSA-1227964] ERBB2 homodimerization [Reaction:R-HSA-1918095] CUL5 mediates ubiquitination of ERBB2 [Reaction:R-HSA-1918092] CHIP (STUB1) mediates ubiquitination of ERBB2 [Reaction:R-HSA-9665726] ERBB2 binds pertuzumab [Reaction:R-HSA-9652264] ERBB2 binds TKIs [Reaction:R-HSA-9652277] ERBB2 binds trastuzumab [Reaction:R-HSA-1963589] ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4
(normalEntity)	[EntityFunctionalStatus:9665307] loss_of_function of ERBB2 T862A:ERBIN:HSP90:CDC37 [plasma membrane] [EntityFunctionalStatus:9665302] loss_of_function of ERBB2 T733I:ERBIN:HSP90:CDC37 [plasma membrane] [EntityFunctionalStatus:9665275] loss_of_function of ERBB2 KD mutants (neratinib resistant):ERBIN:HSP90:CDC37 [plasma membrane] [EntityFunctionalStatus:9665270] loss_of_function of ERBB2 KD mutants (osimertinib resistant):ERBIN:HSP90:CDC37 [plasma membrane] [EntityFunctionalStatus:9665310] loss_of_function of ERBB2 T798M:ERBIN:HSP90:CDC37 [plasma membrane] [EntityFunctionalStatus:9665235] loss_of_function of ERBB2 KD mutants (trastuzumab resistant):ERBIN:HSP90:CDC37 [plasma membrane] [EntityFunctionalStatus:9665277] loss_of_function of ERBB2 KD mutants (AEE788 resistant):ERBIN:HSP90:CDC37 [plasma membrane] [EntityFunctionalStatus:9665279] loss_of_function of ERBB2 KD mutants (lapatinib resistant):ERBIN:HSP90:CDC37 [plasma membrane] [EntityFunctionalStatus:9665966] loss_of_function of ERBB2 TMD/JMD mutants (pertuzumab resistant):ERBIN:HSP90:CDC37 [plasma membrane] [EntityFunctionalStatus:9665378] gain_of_function of ERBB2 ECD mutants:ERBIN:HSP90:CDC37 [plasma membrane] [EntityFunctionalStatus:9664569] gain_of_function of ERBB2 KD mutants:ERBIN:HSP90:CDC37 [plasma membrane] [EntityFunctionalStatus:9820554] gain_of_function of ERBB2 TMD/JMD mutants (TKI sensitive):ERBIN:HSP90:CDC37 [plasma membrane] [EntityFunctionalStatus:9820556] gain_of_function of ERBB2 R678Q:ERBIN:HSP90:CDC37 [plasma membrane] [EntityFunctionalStatus:9820555] gain_of_function of ERBB2 TMD/JMD mutants (trastuzumab):ERBIN:HSP90:CDC37 [plasma membrane] [EntityFunctionalStatus:9665889] gain_of_function of ERBB2 TMD/JMD mutants:ERBIN:HSP90:CDC37 [plasma membrane]

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