Reactome | Drug-mediated inhibition of ERBB2 signaling

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Drug-mediated inhibition of ERBB2 signaling Show undefined attributes

authored	[InstanceEdit:9652267] Orlic-Milacic, Marija, 2019-06-28
created	[InstanceEdit:9652267] Orlic-Milacic, Marija, 2019-06-28
crossReference	[DatabaseIdentifier:12819431] BioModels Database:BIOMD0000000883
dbId	9652282
displayName	Drug-mediated inhibition of ERBB2 signaling
doi	10.3180/R-HSA-9652282.2
edited	[InstanceEdit:9665760] Orlic-Milacic, Marija, 2019-11-01
eventOf	[Pathway:R-HSA-1227986] Signaling by ERBB2 - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-9652264] ERBB2 binds TKIs - Homo sapiens [Reaction:R-HSA-9652277] ERBB2 binds trastuzumab - Homo sapiens [Reaction:R-HSA-9665726] ERBB2 binds pertuzumab - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9652234] Anti-tumor activity of GW572016: a dual tyrosine kinase inhibitor blocks EGF activation of EGFR/erbB2 and downstream Erk1/2 and AKT pathways [LiteratureReference:9652252] A unique structure for epidermal growth factor receptor bound to GW572016 (Lapatinib): relationships among protein conformation, inhibitor off-rate, and receptor activity in tumor cells [LiteratureReference:1237426] Antitumor activity of HKI-272, an orally active, irreversible inhibitor of the HER-2 tyrosine kinase [LiteratureReference:9652226] BIBW2992, an irreversible EGFR/HER2 inhibitor highly effective in preclinical lung cancer models [LiteratureReference:9647026] An Acquired HER2^T798I Gatekeeper Mutation Induces Resistance to Neratinib in a Patient with HER2 Mutant-Driven Breast Cancer [LiteratureReference:9652237] Inhibition of the T790M gatekeeper mutant of the epidermal growth factor receptor by EXEL-7647 [LiteratureReference:9652323] Akt, MAPK (Erk1/2), and p38 act in concert to promote apoptosis in response to ErbB receptor family inhibition [LiteratureReference:9652320] AZD8931, an equipotent, reversible inhibitor of signaling by epidermal growth factor receptor, ERBB2 (HER2), and ERBB3: a unique agent for simultaneous ERBB receptor blockade in cancer [LiteratureReference:9652336] Discovery and pharmacologic characterization of CP-724,714, a selective ErbB2 tyrosine kinase inhibitor [LiteratureReference:9652318] AEE788: a dual family epidermal growth factor receptor/ErbB2 and vascular endothelial growth factor receptor tyrosine kinase inhibitor with antitumor and antiangiogenic activity [LiteratureReference:9652354] p185HER2 monoclonal antibody has antiproliferative effects in vitro and sensitizes human breast tumor cells to tumor necrosis factor [LiteratureReference:9652351] Humanization of an anti-p185HER2 antibody for human cancer therapy [LiteratureReference:9634297] The effects of trastuzumab on HER2-mediated cell signaling in CHO cells expressing human HER2 [LiteratureReference:1227966] Comparison of 3D and 2D tumor models reveals enhanced HER2 activation in 3D associated with an increased response to trastuzumab [LiteratureReference:9665988] Insights into ErbB signaling from the structure of the ErbB2-pertuzumab complex
maxDepth	2
modified	[InstanceEdit:12819426] Weiser, Joel, 2026-02-23
name	Drug-mediated inhibition of ERBB2 signaling
orthologousEvent	[Pathway:R-SPO-9652282] Drug-mediated inhibition of ERBB2 signaling - Schizosaccharomyces pombe [Pathway:R-CEL-9652282] Drug-mediated inhibition of ERBB2 signaling - Caenorhabditis elegans [Pathway:R-DME-9652282] Drug-mediated inhibition of ERBB2 signaling - Drosophila melanogaster [Pathway:R-GGA-9652282] Drug-mediated inhibition of ERBB2 signaling - Gallus gallus [Pathway:R-DRE-9652282] Drug-mediated inhibition of ERBB2 signaling - Danio rerio [Pathway:R-SSC-9652282] Drug-mediated inhibition of ERBB2 signaling - Sus scrofa [Pathway:R-BTA-9652282] Drug-mediated inhibition of ERBB2 signaling - Bos taurus [Pathway:R-CFA-9652282] Drug-mediated inhibition of ERBB2 signaling - Canis familiaris [Pathway:R-RNO-9652282] Drug-mediated inhibition of ERBB2 signaling - Rattus norvegicus [Pathway:R-MMU-9652282] Drug-mediated inhibition of ERBB2 signaling - Mus musculus
releaseDate	2019-12-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9666741] Kancha, Rama Krishna, 2019-11-03
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-9652282
summation	[Summation:9652258] Signaling by ERBB2 can be pharmacologically inhibited with t...

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[Pathway:R-HSA-1227986] Signaling by ERBB2

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