Reactome | pertuzumab [extracellular region]

Schema > ProteinDrug > Entries

compartment	[Compartment:984] extracellular region
componentOf	[Complex:R-HSA-9665973] ERBB2 R678Q:pertuzumab [plasma membrane] - Homo sapiens
consumedByEvent	[FailedReaction:R-HSA-9665708] ERBB2 TMD/JMD mutants do not bind pertuzumab - Homo sapiens [Reaction:R-HSA-9665703] ERBB2 TMD/JMD mutants bind pertuzumab - Homo sapiens [Reaction:R-HSA-9665726] ERBB2 binds pertuzumab - Homo sapiens
created	[InstanceEdit:9665965] Orlic-Milacic, Marija, 2019-11-01
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	9665971
disease	[Disease:1500689] cancer
displayName	pertuzumab [extracellular region]
inDisease	true
maxDepth	1
name	pertuzumab
referenceEntity	[ReferenceTherapeutic:iuphar.ligand:5046] pertuzumab [Guide to Pharmacology:5046]
schemaClass	ProteinDrug
stId	R-ALL-9665971

(input)	[FailedReaction:R-HSA-9665708] ERBB2 TMD/JMD mutants do not bind pertuzumab [Reaction:R-HSA-9665703] ERBB2 TMD/JMD mutants bind pertuzumab [Reaction:R-HSA-9665726] ERBB2 binds pertuzumab
(hasComponent)	[Complex:R-HSA-9665973] ERBB2 R678Q:pertuzumab [plasma membrane] [Complex:R-CFA-9665975] ERBB2:pertuzumab [plasma membrane] [Complex:R-MMU-9665975] ERBB2:pertuzumab [plasma membrane] [Complex:R-HSA-9665975] ERBB2:pertuzumab [plasma membrane]
(activeUnit)	[NegativeRegulation:9665972] Negative regulation by 'ERBB2:pertuzumab:ERBIN:HSP90:CDC37 [plasma membrane]'