Reactome | ERBB2 T798M does not bind afatinib

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ERBB2 T798M does not bind afatinib Show undefined attributes

authored	[InstanceEdit:9665122] Orlic-Milacic, Marija, 2019-10-30
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:9665301] Orlic-Milacic, Marija, 2019-10-30
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	9665311
disease	[Disease:1500689] cancer
displayName	ERBB2 T798M does not bind afatinib
edited	[InstanceEdit:9665760] Orlic-Milacic, Marija, 2019-11-01
entityFunctionalStatus	[EntityFunctionalStatus:9665310] loss_of_function of ERBB2 T798M:ERBIN:HSP90:CDC37 [plasma membrane]
eventOf	[Pathway:R-HSA-9665249] Resistance of ERBB2 KD mutants to afatinib - Homo sapiens
input	[ChemicalDrug:R-ALL-1220577] Afatinib [cytosol] [Complex:R-HSA-9665313] ERBB2 T798M:ERBIN:HSP90:CDC37 [plasma membrane]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9647026] An Acquired HER2^T798I Gatekeeper Mutation Induces Resistance to Neratinib in a Patient with HER2 Mutant-Driven Breast Cancer [LiteratureReference:9652195] Human breast cancer cells harboring a gatekeeper T798M mutation in HER2 overexpress EGFR ligands and are sensitive to dual inhibition of EGFR and HER2
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	ERBB2 T798M does not bind afatinib
normalReaction	[Reaction:R-HSA-9652264] ERBB2 binds TKIs
releaseDate	2019-12-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9662685] Kancha, Rama Krishna, 2019-09-16
schemaClass	FailedReaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9665311
summation	[Summation:9665314] The following ERBB2 KD mutants are resistant to afatinib (BI...

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(hasEvent)

[Pathway:R-HSA-9665249] Resistance of ERBB2 KD mutants to afatinib

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