ERBB2 T798M does not bind afatinib

Stable Identifier
R-HSA-9665311
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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The following ERBB2 KD mutants are resistant to afatinib (BIBW2992):
ERBB2 T798M (Rexer et al. 2013, Hanker et al. 2017);
Literature References
PubMed ID Title Journal Year
28274957 An Acquired HER2T798I Gatekeeper Mutation Induces Resistance to Neratinib in a Patient with HER2 Mutant-Driven Breast Cancer

Hyman, DM, Solit, DB, Nagy, R, Sheehan, JH, Sliwoski, GR, Berger, MF, He, J, Lalani, AS, Brewer, MR, Miller, V, Cross, D, Cutler, RE, Hanker, AB, Lanman, R, Arteaga, CL, Koch, JP, Lovly, CM, Meiler, J

Cancer Discov 2017
23948973 Human breast cancer cells harboring a gatekeeper T798M mutation in HER2 overexpress EGFR ligands and are sensitive to dual inhibition of EGFR and HER2

Song, Y, Estrada, MV, Arteaga, CL, Chakrabarty, A, Narasanna, A, Ghosh, R, Rexer, BN, Engelman, JA

Clin. Cancer Res. 2013
Participants
Participates
Normal reaction
Functional status

Loss of function of ERBB2 T798M:ERBIN:HSP90:CDC37 [plasma membrane]

Status
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Authored
Reviewed
Created
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