MAP2Ks and MAPKs bind to the activated mutant RAF1 complex

Stable Identifier
R-HSA-9656211
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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MAP2Ks and MAPKs bind to the activated mutant RAF1 complex
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MAP2K and MAPK proteins are likely recruited to complexes containing mutant versions of RAF1 proteins, analagous to the wild type pathway, although this has not been explicitly demonstrated in all cases (reviewed in Rauen, 2013).
Literature References
PubMed ID Title Journal Year
23875798 The RASopathies

Rauen, KA

Annu Rev Genomics Hum Genet 2013
Participants
Input
Output
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as an event of
Normal reaction
MAP2Ks and MAPKs bind to the activated RAF complex (Homo sapiens)
Functional status

Gain of function of p21 RAS:GTP:activated RAF1 mutant heterodimers [plasma membrane]

Normal Entity
Disease Entity
Status
Disease
Name Identifier Synonyms
Costello syndrome DOID:0050469 Faciocutaneoskeletal Syndrome, FCS SYNDROME
LEOPARD syndrome DOID:14291 Generalized lentiginosis, Multiple lentigines syndrome, Moynahan syndrome, Cardiocutaneous syndrome, Capute-Rimoin-Konigsmark-Esterly-Richardson syndrome, Lentiginosis profusa syndrome, Gorlin syndrome II, Progressive cardiomyopathic lentiginosis
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Noonan syndrome DOID:3490 Turner's phenotype, karyotype normal (disorder)
hypertrophic cardiomyopathy DOID:11984 familial hypertrophic cardiomyopathy, hypertrophic obstructive cardiomyopathy
Authored
Rothfels, K  (2019-10-25)
Reviewed
Gavathiotis, E  (2020-05-04)
Created
Rothfels, K  (2019-07-27)
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