MAP2Ks and MAPKs bind to the activated mutant RAF1 complex

Stable Identifier
R-HSA-9656211
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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MAP2K and MAPK proteins are likely recruited to complexes containing mutant versions of RAF1 proteins, analagous to the wild type pathway, although this has not been explicitly demonstrated in all cases (reviewed in Rauen, 2013).

Literature References
PubMed ID Title Journal Year
23875798 The RASopathies

Rauen, KA

Annu Rev Genomics Hum Genet 2013
Participants
Participant Of
Normal reaction
Disease
Name Identifier Synonyms
LEOPARD syndrome 14291 Generalized lentiginosis, Multiple lentigines syndrome, Moynahan syndrome, Cardiocutaneous syndrome, Capute-Rimoin-Konigsmark-Esterly-Richardson syndrome, Lentiginosis profusa syndrome, Gorlin syndrome II, Progressive cardiomyopathic lentiginosis
Costello syndrome 0050469 Faciocutaneoskeletal Syndrome, FCS SYNDROME
cancer 162 malignant tumor, malignant neoplasm, primary cancer
Noonan syndrome 3490 Turner's phenotype, karyotype normal (disorder)
hypertrophic cardiomyopathy 11984 familial hypertrophic cardiomyopathy, hypertrophic obstructive cardiomyopathy
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Reviewed
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