Disease-causing mutations in RAS favour the active RAS:GTP bound form and yield constitutively active forms of the protein (reviewed in Prior et al, 2011; Maertens and Cichowski, 2014). Mutations in RAS contribute to cellular proliferation, transformation and survival by activating the MAPK signaling pathway, the AKT pathway and the RAL GDS pathway, among others (reviewed in Stephen et al, 2014; Pylayeva-Gupta et al, 2011)
Maertens, O, Cichowski, K
Pylayeva-Gupta, Y, Grabocka, E, Bar-Sagi, D
Prior, IA, Lewis, PD, Mattos, C
Stephen, AG, Esposito, D, Bagni, RK, McCormick, F
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