Signaling downstream of RAS mutants

Stable Identifier
R-HSA-9649948
Type
Pathway
Species
Homo sapiens
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Disease-causing mutations in RAS favour the active RAS:GTP bound form and yield constitutively active forms of the protein (reviewed in Prior et al, 2011; Maertens and Cichowski, 2014). Mutations in RAS contribute to cellular proliferation, transformation and survival by activating the MAPK signaling pathway, the AKT pathway and the RAL GDS pathway, among others (reviewed in Stephen et al, 2014; Pylayeva-Gupta et al, 2011)

Literature References
PubMed ID Title Journal Year
21993244 RAS oncogenes: weaving a tumorigenic web

Grabocka, E, Pylayeva-Gupta, Y, Bar-Sagi, D

Nat. Rev. Cancer 2011
24814062 An expanding role for RAS GTPase activating proteins (RAS GAPs) in cancer

Cichowski, K, Maertens, O

Adv Biol Regul 2014
22589270 A comprehensive survey of Ras mutations in cancer

Lewis, PD, Mattos, C, Prior, IA

Cancer Res. 2012
24651010 Dragging ras back in the ring

McCormick, F, Stephen, AG, Bagni, RK, Esposito, D

Cancer Cell 2014
Participants
Participates
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Cross References
GlyCosmos
Authored
Reviewed
Created
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