Reactome | RAS mutants bind inactive RAF

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RAS mutants bind inactive RAF Show undefined attributes

authored	[InstanceEdit:5693873] Rothfels, Karen, 2015-05-18
category	binding
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:6802909] Rothfels, Karen, 2015-10-02
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	6802908
disease	[Disease:1500689] cancer
displayName	RAS mutants bind inactive RAF
edited	[InstanceEdit:5674528] Rothfels, Karen, 2015-02-12
entityFunctionalStatus	[EntityFunctionalStatus:6802863] gain_of_function of RAS mutants:GTP [plasma membrane]
eventOf	[Pathway:R-HSA-9649948] Signaling downstream of RAS mutants - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-6803240] Homo- or heterodimerization of RAF downstream of mutant RAS - Homo sapiens [Reaction:R-HSA-6802924] RAF is phosphorylated downstream of oncogenic RAS - Homo sapiens
input	[CandidateSet:R-HSA-6802716] inactive RAF1,BRAF [cytosol] [Complex:R-HSA-6802607] RAS mutants:GTP [plasma membrane]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:6790227] A comprehensive survey of Ras mutations in cancer [LiteratureReference:6790393] RAS oncogenes: weaving a tumorigenic web [LiteratureReference:6799045] Dragging ras back in the ring [LiteratureReference:6790348] In melanoma, RAS mutations are accompanied by switching signaling from BRAF to CRAF and disrupted cyclic AMP signaling [LiteratureReference:5672195] Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF [LiteratureReference:6790449] c-Raf, but not B-Raf, is essential for development of K-Ras oncogene-driven non-small cell lung carcinoma [LiteratureReference:6790250] C-Raf is required for the initiation of lung cancer by K-Ras(G12D) [LiteratureReference:6790404] Selective requirement of PI3K/PDK1 signaling for Kras oncogene-driven pancreatic cell plasticity and cancer [LiteratureReference:6790390] RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF [LiteratureReference:6790370] RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth [LiteratureReference:8933588] Mechanism of RAF isoform switching induced by oncogenic RAS in melanoma [LiteratureReference:6790435] Tumor adaptation and resistance to RAF inhibitors
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	RAS mutants bind inactive RAF
normalReaction	[Reaction:R-HSA-5672950] "Activator" RAF:YWHAB dimer binds RAS:GTP
output	[Complex:R-HSA-6803238] RAS mutants:GTP:RAF [plasma membrane]
precedingEvent	[FailedReaction:R-HSA-6802834] RAS GTPase mutants don't hydrolyze GTP - Homo sapiens
regulatedBy	[PositiveRegulation:R-HSA-8936738] Positive regulation by 'PHB [cytosol]'
releaseDate	2016-09-19
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8933498] Stephens, Robert M, 2016-08-05
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-6802908
summation	[Summation:6802194] Downstream of oncogenic RAS, a number of pathways are activa...

Referrals

(precedingEvent)	[BlackBoxEvent:R-HSA-6803240] Homo- or heterodimerization of RAF downstream of mutant RAS [Reaction:R-HSA-6802924] RAF is phosphorylated downstream of oncogenic RAS
(hasEvent)	[Pathway:R-HSA-9649948] Signaling downstream of RAS mutants

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