Reactome | Amino acids regulate mTORC1

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Amino acids regulate mTORC1 Show undefined attributes

authored	[InstanceEdit:9638279] May, Bruce, 2019-03-04
created	[InstanceEdit:9639278] May, Bruce, 2019-03-09
dbId	9639288
displayName	Amino acids regulate mTORC1
doi	10.3180/R-HSA-9639288.1
edited	[InstanceEdit:9638279] May, Bruce, 2019-03-04
eventOf	[Pathway:R-HSA-9711097] Cellular response to starvation - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:258409] cellular response to amino acid starvation
hasDiagram	true
hasEHLD	false
hasEvent	[BlackBoxEvent:R-HSA-9639287] SESN1,2 binds L-leucine and dissociates from GATOR2 - Homo sapiens [BlackBoxEvent:R-HSA-9640237] CASTOR1 in CASTOR1:CASTOR2 binds L-arginine and dissociates from GATOR2 - Homo sapiens [BlackBoxEvent:R-HSA-9657619] CASTOR1 homodimer binds L-arginine and dissociates from GATOR2 - Homo sapiens [BlackBoxEvent:R-HSA-9640254] BMT2 (SAMTOR) binds S-adenosylmethionine and dissociates from KICSTOR:GATOR1 - Homo sapiens [Reaction:R-HSA-9639286] RRAGC,D exchanges GTP for GDP - Homo sapiens [Reaction:R-HSA-9645598] RRAGC,D hydrolyzes GTP - Homo sapiens [Reaction:R-HSA-9640175] v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine - Homo sapiens [Reaction:R-HSA-9640167] RRAGA,B exchanges GDP for GTP - Homo sapiens [Reaction:R-HSA-9640168] v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine - Homo sapiens [Reaction:R-HSA-9645608] v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 - Homo sapiens [Reaction:R-HSA-9646468] mTORC1 binds RHEB:GTP - Homo sapiens [Reaction:R-HSA-9640195] RRAGA,B hydrolyzes GTP - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9639282] Sestrin2 is a leucine sensor for the mTORC1 pathway [LiteratureReference:9646247] Intersubunit Crosstalk in the Rag GTPase Heterodimer Enables mTORC1 to Respond Rapidly to Amino Acid Availability [LiteratureReference:9647576] Amino Acid Availability Modulates Vacuolar H+-ATPase Assembly [LiteratureReference:9646570] mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H(+)-ATPase [LiteratureReference:9647590] mTOR as a central hub of nutrient signalling and cell growth [LiteratureReference:9647581] Metabolism. Differential regulation of mTORC1 by leucine and glutamine [LiteratureReference:9647579] Recent advances in understanding of amino acid signaling to mTORC1 activation [LiteratureReference:9647592] The Dawn of the Age of Amino Acid Sensors for the mTORC1 Pathway [LiteratureReference:9647589] Lysosomal Regulation of mTORC1 by Amino Acids in Mammalian Cells [LiteratureReference:9639285] Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway [LiteratureReference:9646208] Sestrins inhibit mTORC1 kinase activation through the GATOR complex [LiteratureReference:9646214] The Sestrins interact with GATOR2 to negatively regulate the amino-acid-sensing pathway upstream of mTORC1 [LiteratureReference:9646267] KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1 [LiteratureReference:9646209] Structural mechanism for the arginine sensing and regulation of CASTOR1 in the mTORC1 signaling pathway [LiteratureReference:9646210] Mechanism of arginine sensing by CASTOR1 upstream of mTORC1 [LiteratureReference:9646213] Structural insight into the arginine-binding specificity of CASTOR1 in amino acid-dependent mTORC1 signaling [LiteratureReference:9646218] The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway [LiteratureReference:9640286] SAMTOR is an S-adenosylmethionine sensor for the mTORC1 pathway [LiteratureReference:376999] Rheb binds and regulates the mTOR kinase [LiteratureReference:9646563] Rheb binding to mammalian target of rapamycin (mTOR) is regulated by amino acid sufficiency [LiteratureReference:9647571] Analysis of mTOR signaling by the small G-proteins, Rheb and RhebL1 [LiteratureReference:9647564] The Rheb switch 2 segment is critical for signaling to target of rapamycin complex 1 [LiteratureReference:9647561] Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40 [LiteratureReference:9640284] Ragulator and SLC38A9 activate the Rag GTPases through noncanonical GEF mechanisms [LiteratureReference:8952709] Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1 [LiteratureReference:9646226] mTORC1 Activator SLC38A9 Is Required to Efflux Essential Amino Acids from Lysosomes and Use Protein as a Nutrient [LiteratureReference:8952719] SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1 [LiteratureReference:5653951] The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1 [LiteratureReference:5653913] Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids [LiteratureReference:9646240] A nutrient-induced affinity switch controls mTORC1 activation by its Rag GTPase-Ragulator lysosomal scaffold [LiteratureReference:9646571] Regulation of TORC1 by Rag GTPases in nutrient response [LiteratureReference:5672040] Regulation of TORC1 in response to amino acid starvation via lysosomal recruitment of TSC2 [LiteratureReference:9647598] Twenty-five years of mTOR: Uncovering the link from nutrients to growth [LiteratureReference:9647595] mTOR signaling in stem and progenitor cells
maxDepth	2
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	Amino acids regulate mTORC1
orthologousEvent	[Pathway:R-SCE-9639288] Amino acids regulate mTORC1 - Saccharomyces cerevisiae [Pathway:R-SPO-9639288] Amino acids regulate mTORC1 - Schizosaccharomyces pombe [Pathway:R-DDI-9639288] Amino acids regulate mTORC1 - Dictyostelium discoideum [Pathway:R-CEL-9639288] Amino acids regulate mTORC1 - Caenorhabditis elegans [Pathway:R-DME-9639288] Amino acids regulate mTORC1 - Drosophila melanogaster [Pathway:R-GGA-9639288] Amino acids regulate mTORC1 - Gallus gallus [Pathway:R-XTR-9639288] Amino acids regulate mTORC1 - Xenopus tropicalis [Pathway:R-DRE-9639288] Amino acids regulate mTORC1 - Danio rerio [Pathway:R-SSC-9639288] Amino acids regulate mTORC1 - Sus scrofa [Pathway:R-BTA-9639288] Amino acids regulate mTORC1 - Bos taurus [Pathway:R-CFA-9639288] Amino acids regulate mTORC1 - Canis familiaris [Pathway:R-RNO-9639288] Amino acids regulate mTORC1 - Rattus norvegicus [Pathway:R-MMU-9639288] Amino acids regulate mTORC1 - Mus musculus
releaseDate	2019-09-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9657680] Condon, Kendall J, Sabatini, David M, 2019-08-08
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-9639288
summation	[Summation:9646244] The mTORC1 complex acts as an integrator that regulates tran...

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[Pathway:R-HSA-9711097] Cellular response to starvation

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