Reactome | RRAGC,D exchanges GTP for GDP

Schema > Reaction > Entries

RRAGC,D exchanges GTP for GDP Show undefined attributes

authored	[InstanceEdit:9638279] May, Bruce, 2019-03-04
catalystActivity	[CatalystActivity:9640183] guanyl-nucleotide exchange factor activity of v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GTP [lysosomal membrane]
category	transition
compartment	[Compartment:17938] lysosomal membrane
created	[InstanceEdit:9639278] May, Bruce, 2019-03-09
dbId	9639286
displayName	RRAGC,D exchanges GTP for GDP
edited	[InstanceEdit:9638279] May, Bruce, 2019-03-04
eventOf	[Pathway:R-HSA-9639288] Amino acids regulate mTORC1 - Homo sapiens
followingEvent	[Reaction:R-HSA-9640175] v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine - Homo sapiens
input	[SimpleEntity:R-ALL-29420] GDP [cytosol] [Complex:R-HSA-9640174] v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GTP [lysosomal membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9640284] Ragulator and SLC38A9 activate the Rag GTPases through noncanonical GEF mechanisms
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	RRAGC,D exchanges GTP for GDP
orthologousEvent	[Reaction:R-SCE-9639286] RRAGC,D exchanges GTP for GDP - Saccharomyces cerevisiae [Reaction:R-SPO-9639286] RRAGC,D exchanges GTP for GDP - Schizosaccharomyces pombe [Reaction:R-DDI-9639286] RRAGC,D exchanges GTP for GDP - Dictyostelium discoideum [Reaction:R-CEL-9639286] RRAGC,D exchanges GTP for GDP - Caenorhabditis elegans [Reaction:R-DME-9639286] RRAGC,D exchanges GTP for GDP - Drosophila melanogaster [Reaction:R-GGA-9639286] RRAGC,D exchanges GTP for GDP - Gallus gallus [Reaction:R-XTR-9639286] RRAGC,D exchanges GTP for GDP - Xenopus tropicalis [Reaction:R-DRE-9639286] RRAGC,D exchanges GTP for GDP - Danio rerio [Reaction:R-SSC-9639286] RRAGC,D exchanges GTP for GDP - Sus scrofa [Reaction:R-BTA-9639286] RRAGC,D exchanges GTP for GDP - Bos taurus [Reaction:R-CFA-9639286] RRAGC,D exchanges GTP for GDP - Canis familiaris [Reaction:R-RNO-9639286] RRAGC,D exchanges GTP for GDP - Rattus norvegicus [Reaction:R-MMU-9639286] RRAGC,D exchanges GTP for GDP - Mus musculus
output	[SimpleEntity:R-ALL-29438] GTP [cytosol] [Complex:R-HSA-9640184] v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane]
precedingEvent	[BlackBoxEvent:R-HSA-9639287] SESN1,2 binds L-leucine and dissociates from GATOR2 - Homo sapiens
releaseDate	2019-09-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9657680] Condon, Kendall J, Sabatini, David M, 2019-08-08
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9639286
summation	[Summation:9640245] The Ragulator complex acts as an unconventional guanyl nucle...

Referrals

(hasEvent)	[Pathway:R-HSA-9639288] Amino acids regulate mTORC1
(precedingEvent)	[Reaction:R-HSA-9640175] v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine